药物合成反应习题及答案VIP免费

3写出下列反应产物1，Clf/NaOH/H：OHgCI2药物合成反应习题及答案OHClCl2，OH9,10,OMeO2HBF■NaNOf¥HCbHOO4CuCIheatl/HCf211,/NaNOPhCH2Br/K2CO3DMFFBnO12,13,14,15,AlCl3PhCH——fBr/NaHDMFBnOCH+CH3+3CH2COCH2CH3CHOCHO3NaOEtOCHCH3H2C、CH2OAICI3OHBnOBnO+(C2H5O)2P-CHCOOEt||COOEt3H3CI]H3C3OPhCNaHBnO11COOEtNaOBrheatheatCICHCOOEtNaOEtH2O2/C6H5CNKHCO3/MeOHCH3COOOHOsO”4PyMCPBAC"CNOCCOOEt■CH―3CIOMeOCOOEt2HCH3ORh(Ph3P)3CIO2NW2—*2一NOCOOEtRh(PhP)-GlPhC2—H2COOEtUA|H4・H2/RaneyNi2CH32OHMeO16,17,18,19,20,21,22,23,2425,26,27286,3,4,5,293031333234351,2,BnOBnOH3CO2NClNCNONO2CICOOCIO2NBnONINI「e/NII4Cl2Zn/HClSnCl2丿ElOHRaney^iPd-C/HI3CNCI2NNINI2ClNI2CICOOCHH2NNOLAHH3Pd/CH写出下列反应条件HOBnOOBnOBnOBnPhCHCO/DM「n-Bu4N+「-BnOOBnOBnBu-nNHNH+n-BuNHBnOOBnBnOOBn6,8,9,HOHOCHOHCOOHOH+COClPhICOOHNHBocAC2O/PyOHO-2COOHconcentratedHrefluxO_..—OH3C3CHH3CCOOEtDCC/DMAP■TsOHrefluxCOOMeHO2SO4NHBocPhI!NHAC|PhNaOHOBrHOBrPh3CNa-H3C■OiCH33CHCCCOOEtH3CCH3PhO-H3C3CHH3COCCHCHCHCHCOOEt(iPrO)33Zn/BrCHCOOEtCOOEt3NaOCHCHJonosCOOHHCrOBnOBnOPDCCHOTH~+4/aCetoneCOOEtH34/H2SO_CCH2OHCH3CH3COCHBnOBnOH3C-3CHCOOEtSnCINaOHOH7,10,11,12,13,14,15,16,17,18,19,20,21,6,22,硝酸肺铵(NHAcOHCANOOIICH323,Pb(QAc)AcOHOMEMSeoN|CHOOMEMEZn-Hg/HCICOOHNaBHCH2AI(CO1AI(OPr-i'3+3i-PrOH写出系列反应机理或历程CHOH；OOHOOHNaOHH+CHheatHHCCHCHCH.OHCHcCIH3COH3COH3COCCH2Cl3NHCCCHOOH3C32ClCH3CH2OHH2COHJCHOOIICH3ONaOHOMEMOHC"HClCH3-CH3CH324,26H3COrOMEM272850°CCH3OHCHCH3QICH3OO+O■■■...NICH2COOHCOOH颠茄酮TfCHONOHNH6,2,H3C35,3+(CHClCHCCCIO-CH3四、用简单化合物为原料（或给出的化合物为原料）合成下列目的物MeO3AlClCICH2COOELNaOEt4,CBrH2NaOH5,CH2N2Ag^OH2OHOHOCOOHBnOBnO2MeOHC-OCH匚0CH2OH