Amidation of Carboxylic Acids:preparation of Acetanilide Chen Xiaoling Class2 2012364217 一、Purpeses and Requirements ⑴Learn the principles and operation of aniline aceltylation
⑵Consolidate the recrystallization method and the principle of purflication of organic compounds
二、The experimental princinple and devices
Principle Acetanilide can be prepared from aniline in several ways, using acetyl chloride,acetic anhydride or glacial acetic acid as starting materials
Acetyl chloride reacts very vigorously
Acetican hydride is preferred for a laboratory synthesis because its rate of hydrolysis is low enough to allow the acetylation of amine to be carried out in aqueous solution
It gives a product of high purity and in good yield
The procedure with glacial is of commercial interest since it
