2025年结直肠癌肝转移综合治疗新策略VIP免费

结直肠癌肝转移综合治疗新方略 作者：王伟军 胡志前来源：《上海医药》第 16 期 摘 要 结直肠癌是消化道最常见的恶性肿瘤之一。肝脏是结直肠癌最重要的转移器官，仅有 核心词 结直肠癌 肝转移 多学科综合治疗 中图分类号：R735.3+5 文献标记码：A 文章编号：1006-1533（）16-0004-05 The novel strategy for treatment of patients with colorectal liver metastases by multi-disciplinary team WANG Weijun ， HU Zhiqian （Changzhen Hosptital of the Second Military Medical University ， Shanghai 03 ， China） ABSTRACT Colorectal cancer is one of the most common malignant tumors of digestive tract. The liver is a frequent site of metastatic colorectal disease. Only less than 20% of colorectal liver metastases （CRLM ） can be surgically resected ， so that the liver metastases is one of the important causes of death in patients with CRLM. For this reason ， a lot of the “guidelines for diagnosis and treatment” and “criterion” for CRLM were formulated at home and abroad. Because of the uneven medical levels in various hospitals of China ， it is difficult to completely follow the “guidelines” and “criterion” in treatment of CRLM. Therefore ， this article summarizes therapeutic measures suitable for majority of doctors in treatment of CRLM including surgery ， neoadjuvant chemotherapy and adjuvant chemotherapy ， local treatment and multi-disciplinary treatment. KEY WORDS colorectal cancer ； liver metastases ； multi-disciplinary treatment 结直肠癌肝转移（colorectal liver metastasis，CRLM）是结直肠癌在进展中最容易发生的生物学事件之一。有 15%～25%的结直肠癌患者在确诊时即伴有肝转移，另有 15%～25%患者在原发灶根治术后发生肝转移，其中绝大多数（80%～90%）的肝转移灶无法获得根治性切除。肝转移也是结直肠癌最重要的致死因素之一[1]。在结直肠癌死亡患者的尸体解剖中，发现约1/3 患者肝脏是唯一的转移部位[2]。某...