AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess自身免疫性疾病AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess一.概述1.基本概念自身免疫autoimmunity自身免疫病autoimmunedisease机体对自身成分发生免疫应答的现象………………………………..而导致的疾病状态AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess自身免疫生理性病理性清除衰老和损伤细胞、平衡应答水平、维持自身稳定生理状态已知可测出的一些自身抗体：肌动蛋白、肌凝蛋白、角蛋白、DNA、细胞色素C、胶原、髓鞘碱性蛋白、2微球蛋白、白蛋白、铁蛋白、IgG、各种激素自身免疫病AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess2.自身免疫病的基本特征血液中可测到高效价的自身抗体和/或自身应答性T淋巴细胞自身抗体或自身应答性T淋巴细胞造成相应的组织细胞损伤或功能障碍病情的转归与自身免疫应答的强度密切相关反复发作和慢性迁延AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess3.分类器官特异性器官非特异性又称全身性或系统性AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess器官特异性：毒性弥漫性甲状腺肿（Graves病）原发性肾上腺皮质萎缩（Addison病）慢性溃疡性结肠炎I型糖尿病重症肌无力非器官特异性：（系统性）类风湿性关节炎系统性红斑狼疮（SLE）自身免疫病的分类AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess二.自身免疫病的免疫损伤机制及典型疾病1.以自身抗体引起的损害细胞或基底膜破坏功能紊乱免疫复合物沉积自身免疫性溶血性贫血、肺出血肾炎综合征Graves病、重症肌无力SLEAsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess系统性红斑狼疮（SLE）：自身细胞核抗原IgG型自身抗体复合物沉积于肾小球、关节和其它器官的细胞壁细胞损伤释放更多的核抗原AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcessAsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess2.自身反应性T细胞引起的损害：胰岛素依赖型糖尿病（IDDM）：CD8+CTL对胰岛的细胞发生免疫应答实验性变态反应性脑脊髓膜炎（EAE）：髓鞘碱性蛋白（MBP）多发性硬化症AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess三.自身免疫性疾病的发生的相关因素AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess1.免疫隔离部位抗原的释放：精子、眼内容物、神经髓鞘磷脂碱性蛋白手术、外伤、感染交感性眼炎、自身免疫性睾丸炎2.自身抗原发生改变：生物、物理、化学（包括药物）等因素AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess肺炎支原体感染红细胞抗原改变变性IgG抗自身IgG抗体（类风湿因子）中性粒细胞吞噬病原体时释放的溶酶体酶多种药物如甲基多巴血细胞抗原改变如肼苯哒嗪、普鲁卡因酰胺、异烟肼SLE样综合征AsymptomaticulcerativecolitispatientsonanProDepressionARiskFactorforInfantMentalHealthMammographyBenchmarksAngoffProcess3.分子模拟（或交叉抗原）微生物抗原自身抗原相似决定基（或交叉抗原...
