甲基醚的脱甲基反应 -060120 药明康德内部保密资料经典化学合成反应标准操作甲基芳基醚去甲基化反应编者：彭作中经典合成反应标准操作—酚醚去甲基化反应药明康德新药开发有限公司药明康德内部保密资料Page 1 of 21 药明康德新药开发有限公司化学合成部经典合成反应标准操作—酚醚去甲基化反应药明康德新药开发有限公司药明康德内部保密资料Page 2 of 21 目录1．前言 ................................................................................................................. 32．酸性试剂 ......................................................................................................... 32.1．浓 HI ，HBr ，HCl ............................................................................................. 32.2．48% HBr 加入相转移催化剂 ........................................................................... 42.3．BBr3, BI 3, BCl3 ................................................................................................... 52.4．BX3 和 Me2S 的络合物 ....................................................................................... 62.5．BBr3/NaI/15-crown-5 ......................................................................................... 82.6．Me2BBr ............................................................................................................... 92.7．AlX 3/CH 3CN, AlX 3/CH 2Cl2, ............................................................................ 102.8．AlBr 3/EtSH，AlCl 3/EtSH, AlCl 3/HSCH 2CH 2SH，AlCl 3/EtSH/CH 2Cl2 .... 103．碱性试剂 ....................................................................................................... 113.1．氨基钠 ............................................................................................................... 113.2．N-甲基苯基氨基钠 /HMPT .............................................................................. 113.3．EtSNa .......................................................................................................
