治疗性抗体和抗体工程VIP免费

IntroductiontoTherapeuticAntibodySpeaker：蔡泽蕲010203BasicKnowledgeofAntibodyAntibodyEngineeringIssuesandProspectONTENTSCChapter01BasicKnowledgeofAntibodyImmunesystemClassificationofantibodyStructureofantibodyMonoclonalAntibodyImmuneSystemInnateimmunesystem：Adaptiveimmunesystem：Responseisnon-specificNoimmunologicalmemoryFoundinnearlyallformsoflifePathogenandantigenspecificresponseImmunologicalmemoryFoundonlyinjawedvertebratesAdaptiveimmunesystemClassificationofantibodyIsotypesofnaturalantibodies:IgA、IgD、IgE、IgG、IgMClassSubclassRatioIgA210%～15%IgD20.2%IgE1~IgG475%～80%IgM15%～10%StructureofantibodyStructureofantibody(PDBID:5DK3)CrystalStructureofPembrolizumab,afulllengthIgG4antibodyAntibodygenerearrangementMonoclonalAntibodyChapter02AntibodyEngineeringTechnologiesforantibodyengineeringTypesofengineeredantibodyResearchStatusFamoustherapeuticantibodiesTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesEBVtransformationTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesHeterohybridomasTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesHeterohybridomasTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesPhagedisplayTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesYeastdisplayTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesRecombinantDNAtechnologiesTechnologiesforantibodyengineeringHybridomatechnologyEBVtransformationHeterohybridomasHumanhybridomasDisplaytechnologiesPhagedisplayYeastdisplayBacterialdisplayKeyrecombinantDNAtechnologiesProteinexpressiontechnologiesTypesofengineeredantibodyChimericantibodyHumanizedantibodyCDRgraftingSDRgraftingAntibodyfragmentsFabscFvdAbBispecificantibodiesFcFPsAntibody-drugconjugates(ADC)Typesofengineeredantibody...