精品文档---下载后可任意编辑EGCG 通过抑制溶酶体途径增强宫颈癌细胞对顺铂的敏感性的开题报告【摘要】目前，顺铂是治疗宫颈癌最常用的化疗药物。然而，长期的顺铂使用会导致多种副作用和耐药性。因此，寻找辅助治疗方法已成为缓解这种副作用和提高疗效的重要途径。EGCG 是从绿茶中提取的一种多酚类化合物，已被证明具有抗癌和抗氧化性质。本讨论旨在讨论EGCG 对宫颈癌细胞对顺铂的敏感性的影响，并探讨其机制。结果表明，EGCG 可以通过抑制溶酶体途径来增强宫颈癌细胞对顺铂的敏感性。同时，EGCG 还能够促进细胞凋亡，并抑制细胞增殖和迁移。综上所述，EGCG 可能是一种潜在的辅助治疗宫颈癌的方法，可以提高顺铂的疗效并缓解其副作用。【关键词】EGCG；宫颈癌；顺铂；溶酶体途径；细胞凋亡【Abstract】Currently, cisplatin is the most commonly used chemotherapy drug for the treatment of cervical cancer. However, long-term use of cisplatin can cause various side effects and drug resistance. Therefore, finding adjuvant therapy has become an important way to alleviate these side effects and improve efficacy. EGCG is a polyphenolic compound extracted from green tea, which has been proven to have anti-cancer and antioxidant properties. The aim of this study is to investigate the effect of EGCG on the sensitivity of cervical cancer cells to cisplatin and explore its mechanism. The results showed that EGCG could enhance the sensitivity of cervical cancer cells to cisplatin by inhibiting the lysosomal pathway. At the same time, EGCG can promote cell apoptosis, and inhibit cell proliferation and migration. In conclusion, EGCG may be a potential adjuvant therapy for cervical cancer, which can enhance the efficacy of cisplatin and alleviate its side effects.【Keywords】EGCG; cervical cancer; cisplatin; lysosomal pathway; cell apoptosis
