精品文档---下载后可任意编辑TACC3 和 p53 在膀胱移行细胞癌中的表达及其临床意义的开题报告摘要：膀胱移行细胞癌是膀胱癌的一种亚型，其恶性程度较高，预后不良。本讨论旨在探讨 TACC3 和 p53 在膀胱移行细胞癌中的表达及其临床意义。通过收集 50 例膀胱移行细胞癌患者的组织样本，采纳免疫组织化学方法检测 TACC3 和 p53 的表达情况，并分析其与患者临床病理特征以及预后的关系。结果显示，TACC3 和 p53 在膀胱移行细胞癌中的阳性表达率分别为 60%和 48%，且两者的表达呈现显著的正相关性。同时，TACC3 和 p53 的表达与患者的肿瘤分期、淋巴结转移及生存率相关。该讨论结果表明，TACC3 和 p53 的表达可作为膀胱移行细胞癌预后评估和治疗靶点的候选指标。关键词：膀胱移行细胞癌；TACC3；p53；免疫组织化学；预后Abstract:Bladder urothelial carcinoma is a subtype of bladder cancer with high malignancy and poor prognosis. The purpose of this study is to investigate the expression of TACC3 and p53 in bladder urothelial carcinoma and their clinical significance. Immunohistochemical method was used to detect the expression of TACC3 and p53 in 50 tissue samples from bladder urothelial carcinoma patients, and their relationship with clinical pathological characteristics and prognosis of the patients was analyzed. The results showed that the positive expression rates of TACC3 and p53 in bladder urothelial carcinoma were 60% and 48%, respectively, and there was a significant positive correlation between them. Moreover, the expressions of TACC3 and p53 were correlated with tumor stage, lymph node metastasis and survival rate of the patients. These results suggest that the expression of TACC3 and p53 may be potential prognostic and therapeutic targets for bladder urothelial carcinoma.Keywords: bladder urothelial carcinoma; TACC3; p53; immunohistochemistry; prognosis
