精品文档---下载后可任意编辑复合明胶微球的 α-TCP/α-CSH 骨水泥支架的制备及载药讨论的开题报告摘要复合明胶微球的 α-TCP/α-CSH 骨水泥支架是一种新型骨修复材料，具有良好的生物相容性和生物活性，可在体内逐渐降解并逐渐释放药物，具有潜在的应用前景。本讨论旨在制备该种复合材料，并对其进行载药讨论。本讨论将采纳溶胶凝胶法和水热合成法结合的方法制备 α-TCP/α-CSH 骨水泥，同时加入复合明胶微球，制备成支架。通过反应时间、反应温度等条件优化，得到较合理的制备工艺。制备好的支架经扫描电子显微镜和 X 射线衍射分析表明，复合明胶微球分布均匀，形态完整，骨水泥也具有较好的结晶性和相应的化学元素。通过将药物埋入复合明胶微球中，并将其加入制备好的支架中，制成载药复合支架。通过离体释放试验，讨论复合明胶微球的 α-TCP/α-CSH 骨水泥支架的载药和释药性能，并对不同药物的载药和释药性能进行比较讨论。关键词：复合明胶微球；α-TCP/α-CSH 骨水泥支架；载药；释药AbstractComposite gelatin microspheres containing α-TCP/α-CSH bone cement scaffolds are a new type of bone repair material with good biocompatibility and bioactivity. It can gradually degrade and release drugs in the body, and has potential application prospects. The purpose of this study is to prepare this composite material and conduct drug loading research.In this study, the α-TCP/α-CSH bone cement will be prepared by combining the sol-gel method and the hydrothermal synthesis method, and the composite gelatin microspheres will be added to prepare the scaffold. By optimizing the reaction time, reaction temperature and other conditions, a more reasonable preparation process can be obtained. The prepared scaffold was analyzed by scanning electron microscopy and X-ray diffraction, and the results showed that the composite gelatin microspheres were evenly distributed with an intact morphology, and the bone cement had good crystallinity and corresponding chemical elements.精品文档---下载后可任意编辑By burying drugs in composite gelatin microspheres and adding them to the prepared scaffold, drug-loaded composite scaffolds were prepared. Through in vitro release experiments, the drug loading and releasing properties of the composite gelatin microspheres containing α-TCP/α-CSH bone cement scaffold were studied, and the drug loading and releasing properties of different drugs were compared.Keywords: Composite gelatin microspheres; α-TCP/α-CSH bone cement scaffold; Drug loading; Drug release
