精品文档---下载后可任意编辑七氟醚吸入麻醉对老年大鼠认知功能的影响及姜黄素对其的干预效应的开题报告题目：七氟醚吸入麻醉对老年大鼠认知功能的影响及姜黄素对其的干预效应摘要：随着人口老龄化的加剧，老年人麻醉手术的数量不断增加，但麻醉药对老年人的认知功能影响却备受关注。本讨论旨在探究七氟醚吸入麻醉对老年大鼠认知功能的影响，并测试姜黄素对其的干预效应。将 24 只 18 个月大的雄性 Sprague-Dawley 大鼠随机分为四组：对比组、姜黄素组、七氟醚组和姜黄素+七氟醚组。四组大鼠接受不同的处理，然后进行 Morris 水迷宫测试、Y-迷宫测试和新颖目标测试。结果显示，七氟醚吸入麻醉对老年大鼠认知功能产生了显著的影响，表现为学习、记忆和空间定向能力的减退；而姜黄素能够显著减轻七氟醚对老年大鼠认知功能的影响。因此，讨论结果表明姜黄素可能具有保护老年人认知功能的潜力，在老年人麻醉手术中可能具有重要的临床应用价值。关键词：七氟醚、老年大鼠、认知功能、姜黄素、干预Abstract: With the aging population, the number of anesthesia surgeries in the elderly is increasing, but the effect of anesthesia on cognitive function in the elderly is concerning. This study aims to investigate the effect of sevoflurane inhalation anesthesia on cognitive function in elderly rats and to test the intervention effect of curcumin. Twenty-four 18-month-old male Sprague-Dawley rats were randomly divided into four groups: control group, curcumin group, sevoflurane group, and curcumin + sevoflurane group. The rats in the four groups received different treatments and then underwent Morris water maze test, Y-maze test, and novel object recognition test. The results showed that sevoflurane inhalation anesthesia had a significant effect on cognitive function in elderly rats, manifested as a decline in learning, memory, and spatial orientation abilities; while curcumin could significantly alleviate the effect of sevoflurane on cognitive function in elderly rats. Therefore, the results of the study indicate that curcumin may have the potential to protect cognitive function in the elderly and may have important clinical application value in anesthesia surgery in the elderly.Keywords: sevoflurane, elderly rats, cognitive function, curcumin, intervention
