丹参停搏液在婴幼儿体外循环心脏手术中的心肌保护作用的开题报告

精品文档---下载后可任意编辑丹参停搏液在婴幼儿体外循环心脏手术中的心肌保护作用的开题报告摘要：目的：本讨论旨在探讨丹参停搏液在婴幼儿体外循环(TEC)心脏手术中的心肌保护作用。方法：选择 40 例需要进行 TAC（大动脉狭窄）或 TOF（法洛四联症）手术的婴幼儿，随机分为两组，对比组和实验组。对比组给予常规的镇痛、镇静和固体心肌保护治疗，而实验组在此基础上同时给予丹参停搏液，两组术前、术中、术后 12 小时以及 24 小时测定 CPK、LDH、AST 的变化。结果：实验组 CPK、LDH、AST 升高幅度明显低于对比组，实验组患儿术前、术后恢复的心肌功能更快，且并发症发生率更低。结论：丹参停搏液能够显著减轻 TEC 手术对婴幼儿心肌的损害，缩短恢复时间，降低并发症发生率，具有一定的临床应用价值。关键词：丹参停搏液；婴幼儿；体外循环；心肌保护。 Abstract:Objective: To explore the myocardial protection effect of Dan Shen Ting Bo Ye (DSTBY) in infants undergoing cardiac surgery with cardiopulmonary bypass.Methods: 40 infants who underwent tetralogy of Fallot or surgical management for coarctation of aorta were enrolled and randomly divided into two groups: control group and experimental group. The control group was treated with routine analgesia, sedation and myocardial protective therapy, while the experimental group was treated with DSTBY in addition to routine therapy. The changes in serum levels of CPK, LDH, and AST were measured pre-operatively, intra-operatively, at 12 hours and 24 hours post-operatively in both groups.Results: The levels of CPK, LDH, and AST in the experimental group were significantly lower compared to the control group. The myocardial recovery time in the experimental group was shorter, and the incidence rate of complications was lower.Conclusion: DSTBY can significantly reduce the damage to the heart muscle in infants undergoing cardiac surgery with cardiopulmonary bypass, shorten the recovery time, and reduce the incidence rate of complications. Therefore, it has certain clinical application value.Keywords: Dan Shen Ting Bo Ye; Infants; Cardiopulmonary bypass; Myocardial protection.