精品文档---下载后可任意编辑人工血管携腺病毒介导血管内皮生长因子基因对内皮细胞功能的影响的开题报告【摘要】随着心血管疾病的发病率不断攀升，人工血管的讨论在临床治疗中越来越受到重视。本讨论主要旨在利用腺病毒介导的内皮生长因子基因组装人工血管，评估其在内皮细胞功能方面的影响。通过体外细胞培育实验和动物试验，探究人工血管的组织学特征、生物学特性及其对细胞增殖、迁移和血管形成的影响，为人工血管的临床应用提供理论和实验基础。估计本讨论结果将有望在人工血管的制备和功能维持方面做出创新性贡献。【关键词】人工血管、腺病毒、内皮生长因子、内皮细胞、生物学特性、血管形成【Abstract】With the increasing incidence of cardiovascular disease, the research of artificial blood vessels has been received more and more attention in clinical treatment. The aim of this study is to assemble artificial blood vessels using adenovirus-mediated endothelial growth factor gene, and evaluate their impact on endothelial cell function. Through in vitro cell culture experiments and animal experiments, we explored the histological characteristics, biological properties, and their effects on cell proliferation, migration and vascular formation of artificial blood vessels, to provide theoretical and experimental basis for the clinical application of artificial blood vessels. Our study is expected to make innovative contributions in the preparation and functional maintenance of artificial blood vessels.【Keywords】Artificial blood vessel, Adenovirus, Endothelial growth factor, Endothelial cell, Biological properties, Vascular formation.
