精品文档---下载后可任意编辑鞘内注射甲氨喋呤致中枢神经系统不良反应调查的开题报告【摘要】为了探讨鞘内注射甲氨喋呤致中枢神经系统不良反应的原因和机制，本讨论采纳问卷调查、实验室检测等方法进行讨论。结果显示，鞘内注射甲氨喋呤可引起中枢神经系统不良反应，其机制可能与药物在注射部位扩散至脑室系统和脑膜引起炎症反应有关。此外，病人个体差异和剂量选择也可能是影响不良反应的因素。【关键词】鞘内注射；甲氨喋呤；中枢神经系统；不良反应；调查【Abstract】To investigate the causes and mechanisms of central nervous system adverse reactions induced by intrathecal injection of methotrexate, this study used questionnaire survey and laboratory testing. The results showed that intrathecal injection of methotrexate can cause adverse reactions in the central nervous system, and the mechanism may be related to the diffusion of the drug to the ventricular system and meninges, causing inflammatory reaction. In addition, individual differences in patients and dose selection may also be factors affecting adverse reactions.【Keywords】intrathecal injection; methotrexate; central nervous system; adverse reactions; survey
