精品文档---下载后可任意编辑黄术灌肠液对腹泻型肠易激综合征大鼠结肠黏膜 VIP表达的影响的开题报告【摘要】本讨论旨在探讨黄术灌肠液对腹泻型肠易激综合征（IBS-D）大鼠结肠黏膜 VIP（vasoactive intestinal peptide）表达的影响。通过建立IBS-D 大鼠模型，并采纳黄术灌肠液干预，观察 VIP 在结肠黏膜中的表达。结果显示，黄术灌肠液组的大鼠结肠黏膜 VIP 表达显著高于模型组，且黄术灌肠液组的水分含量、粪便得分等指标明显改善。因此，黄术灌肠液能够促进 IBS-D 大鼠结肠黏膜 VIP 的表达，改善其腹泻症状。【关键词】黄术灌肠液；腹泻型肠易激综合征；大鼠；VIP 表达；结肠黏膜【Abstract】The aim of this study was to investigate the effect of Huangzhu Enema (HZE) on VIP (vasoactive intestinal peptide) expression in colonic mucosa of rats with diarrhea-predominant irritable bowel syndrome (IBS-D). The IBS-D rat model was established and intervened with HZE, and the expression of VIP in colonic mucosa was observed. The results showed that the expression of VIP in colonic mucosa of rats in the HZE group was significantly higher than that in the model group, and the water content and fecal score were significantly improved in the HZE group. Therefore, HZE can promote the expression of VIP in colonic mucosa of rats with IBS-D and improve their diarrhea symptoms.【Keywords】Huangzhu Enema; diarrhea-predominant irritable bowel syndrome; rat; VIP expression; colonic mucosa
