文献抄读精致 PPT 模板 1 1、TrendsinMortalityFromAllCausesAmongHypertensiveAdultsintheUnitedStates2024-05-16 名目1Background2Methods3Results4DisscussionBackgroundThisarticlereviewstheepidemiologyofADHFandtheprofileofpatientssufferingfromthiscondition.Itdescribesfactorsusedinassessingprognosisandpresentstreatmentoptions.Altho 2、ughnocurrentlyavailabletreatmentshavebeenshowntofavorablyaffectlong-termoutcomes,thereareavarietyofstrategiesandapproachestomanagementthatareexpectedtoreducemorbidityandmortalityfollowingdischargeafterADHFhospitalization.MethodsTheimportanceofthetransitionfromhospitaltotheoutpatientsettingisdes 3、cribed.Particularattentionshouldbefocusedonprovidinghealtheducationtothepatientandtheirfamilyatanappropriatelevelofmedicalliteracyaswellasensuringearlyfollow-upevaluationafterhospitaldischarge.ResultsReleaseofaldosteroneisstimulatedbydecreasedrenalperfusionviaangiotensinII,hyperkalemia,andpossi 4、blyadrenocorticotropichormone.2Aldosteroneexertsitseffectsbybindingtomineralocorticoidreceptorsinrenalepithelialcells.Aldosteronehasseveraldeleteriouseffectsonthefailingheart,primarilysodiumandfluidretention,butalsoendothelialdysfunction,leftventricularhypertrophy,andmyocardialfibrosis.2,3Plasm 5、aaldosteronelevelscanbemarkedlyelevatedinpatientswithheartfailure,likelyduetoactivationofthereninangiotensin-aldosteronesystem.ElevatedaldosteroneandangiotensinIIlevelshavebeenassociatedwithhighermortalityratesDisscussionWhilethedifferencesbetweenthetwodrugsremaintobedetermined,themostimportant 6、differencesinclinicalpracticeareselectivityforreceptors(andhencetheirantiandrogenicsideeffects)andprice.Eventhoughitisavailableasagenericdrug,eplerenonestillcostsatleastthreetimesmorethanspironolactoneforthesamedosageandindication.DisscussionThepharmacologicdifferencesbetweenthetwoARAshavebeend 7、escribedearlier,andguidelineshaveadvocatedevidence-baseduseofARAsfortheirrespectiveindications.Therehavebeennolarge-scale,head-to-headcomparisonsofspironolactonea...
