星点设计﹣效应面法研究水蛭炮制工艺目 录摘要…………………………………………………………………………… Ⅰ-Ⅱ1 前言..............................................................12 材料与仪器........................................................22.1 药材............................................................22.2 试剂与仪器......................................................22.3 药材的前处理....................................................32.4 试液的制备......................................................33 方法..............................................................43.1 星点设计﹣效应面法实验设计......................................43.2 质量评价指标....................................................54 结果..............................................................65 讨论.............................................................156 结论.............................................................18参考文献...........................................................19综述...............................................................21致谢...............................................................28星点设计﹣效应面法研究水蛭炮制工艺摘要:目的 采用星点设计-效应面法优选滑石粉烫水蛭（Hirudo nipponica Whitman）的最佳工艺；方法 以滑石粉烫水蛭炮制温度、炮制时间、滑石粉用量为考察因素对水蛭进行炮制，以水蛭粉碎率、醇溶性浸出物、抗凝血酶活性为质量指标，对结果进行多元非线性回归拟合，优选出水蛭炮制的最佳工艺；结果 最佳炮制工艺参数为炮制温度为 172℃、炮制时间为 5 min、滑石粉用量为 29%；结论 通过星点设计﹣效应面法优选滑石粉烫水蛭工艺，结果可靠，预测性良好。关键词：水蛭；星点设计﹣效应面法；炮制IOptimization of Process Based on Central Composite Design and Response Surface Methodogy for HirudoAbstract: Objective To optimize the talc scorch process for Hirudo by central composite design response surface methodology. Methods The investigation factors of scorch quality were scorch temperature,...
