CLU的基因多态性与非痴呆型血管认知障碍相关性的研究

CLU 的基因多态性与非痴呆型血管认知障碍相关性的研究 蒋子贺1，尹昌浩 1、2，朱晓峰 3摘要：目的:探讨 CLU 基因多态性与 VCIND 患者之间的相关性。 方法:收集 VCIND研究组患者 44 例,认知正常对照组 23 例，记录人口学资料、危险因素、现病史、既往史，进行神经系统查体、神经心理学量表评分及核磁共振检查。检测和分析两组 CLU 基因 rs11136000snp、rs93311888snp 位点，比较 CLU 基因多态性与VCIND 患者及其影像学之间的相关性。 结果:(1)VCIND 组与认知正常组的rs11136000snp 位点对比，P＜0.05，差异有统计学意义。rs9331888snp 位点的 P＞0.05，无显著性差异。（2）VCIND 组与对照组 SVD 总分对比，P＜0.05，存在显著性。（3）CLU 基因多态性与 VCIND 患者的影像学比较，P＜0.05，存在显著性。 结论：CLU 基因多态性与 VCIND 具有相关性；CLU 基因的两个 snp 位点均与 VCIND 患者的影像学存在交互作用。关键词：CLU 基因多态性；非痴呆型血管认知障碍；磁共振成像；交互作用 Study on the correlation between gene polymorphism of CLU and non-dementia vascular cognitive impairmentJiang Zi-he,Mudanjiang Medical University,Mudanjiang city, heilongjiang province,157000Yin Chang-hao,Mudanjiang Medical University,Mudanjiang city, heilongjiang province,157000Zhu Xiao-feng,Mudanjiang Medical University Hongqi Hospital,Mudanjiang city, heilongjiang province,157000Objective: to investigate the correlation between CLU gene polymorphism and VCIND. Methods: 44 patients in VCIND study group and 23 patients in cognitive control group were collected. Demographic data, risk factors, history of present illness and previous history were recorded. The rs11136000snp and rs93311888snp of two groups of CLU genes were detected and analyzed, and the correlation between CLU gene polymorphism and VCIND patients and their imaging was compared. Results :(1) the rs11136000snp of the VCIND group and the cognitively normal group were compared, and the difference was statistically significant (P < 0....