基于稳态模型探索胰岛素抵抗与非糖尿病性缺血性卒中不良功能预后的研究目录缩略词表............................................................4缩略词表............................................................5研究一、基于稳态模型探索胰岛素抵抗与非糖尿病急性缺血性卒中患者不良功能预后的关系................................................5研究二、伴 IR 的 2 型糖尿病轻度认知障碍患者脑代谢变化特征的核磁共振研究............................................................7ABSTRACT............................................................7文献综述...........................................................141.胰岛素抵抗.......................................................141.1 概述.......................................................141.2 IR 的发病机制...............................................142 .IR 与缺血性脑卒中...............................................153. IR 在缺血性脑卒中发生发展中的作用...............................163.1 干扰脂代谢.................................................173.2 高血糖.....................................................183.3 高血压.....................................................193.4 ET 增高，促血小板聚集功能亢进...............................193.5 血管内皮损伤...............................................203.6 纤溶系统的异常.............................................203.7 全身性炎性反应.............................................213.8 其他.......................................................214 . IR 对缺血性脑卒中预后的影响....................................215 . IR 与认知功能障碍..............................................226. IR 认知功能障碍的机制...........................................226.1 Aβ 的沉积..................................................226.2 IR 与 tau 蛋白过度磷酸化....................................236.3 IR 与铁代谢.................................................246.4 胰岛素信号途径受损.........................................25研究一、基于稳态模型探索...
