长沙医学院毕业设计(论文)课题名称Cyc与β2-MG在糖尿病肾病早期诊断中的应用价值学生姓名廖诗瑶学号院(系)、年级专业医学检验系指导教师李子博职称副教授2017年5月20日目录中文摘要......................................................................................................................I英文摘要.....................................................................................................................II前言...............................................................................................................................11材料与方法............................................................................................................2病例来源.............................................................................................................21.2试剂与仪器........................................................................................................21.3方法......................................................................................................................2统计学方法........................................................................................................22结果..........................................................................................................................3两组血清Cyc、β2-MG含量的比较...........................................................32.2两项指标单一检测与联合检测阳性率的比较.......................................3单一检测与联合检测灵敏度与特异度的比较.......................................43讨论..........................................................................................................................5结论...............................................................................................................................7参考文献.....................................................................................................................8致谢...............................................................................................................................9综述.............................................................................................................................10摘要目的探讨在糖尿病肾病患者血清中联合检测Cyc和β2-MG含量对早期诊断的临床应用价值。方法选择2016年1月至2017年1月在南华大学附属第一医院住院确诊为糖尿病肾病的60例患者作为实验对象，设为研究组。选择同一时间段在南华大学附属第一医院接受体检的60例正常健康者，设为对照组。对比在单项检测时研究组与对照组两组患者血清中的Cyc和β2-MG的含量，和联合检测时血清中的阳性率，特异度与敏感度。结果在对糖尿病肾病的临床诊断中，糖尿病肾病患者血清中Cyc与β2-MG含量显著升高。两组相比较，其检验差异有统计学意义（);其中，研究组患者血清中Cyc的阳性率为73.3%，β2-MG的阳性率为58.3%，两者联合检测的阳性率高达90.0%。联合检测糖尿病肾病患者血清Cyc与β2-MG的阳性率与灵敏度均明显高于其单项检测，差异均具有统计学意义（）；但其特异度无明显差别，差异无统计学意义(P>)。结论通过对血清Cyc与β2-MG的检测，发现其是诊断糖尿病肾病早期诊断的重要指标，联合检测有利于提高患者的检出率，具有较高的临床价值。关键词：胱抑素C；β2-微球蛋白；糖尿病肾病ABSTRACTObjective:ToexploretheclinicalvalueofjointdetectionofCycandβ2-MGinbloodinearlydiagnosisofdiabeticnephropathy.Methods60patientswithdiabeticnephropathyinourhospitalfromJanuary2016toJanuary2017wereselectedastheresearchgroup.Meanwhile,60healthypeopleafterphysic...
