快速眼动睡眠期行为障碍(RBD)的帕金森病临床特征分析 VIP免费

biomed.cnjournals.comProgressinModemBiomedicineVoL21NO.6MAR2021doi:10.1324l/j.cnki.pmb.2021.06.039快速眼动睡眠期行为障碍(RBD)的帕金森病临床特征分析*张靖1吴小云2王俊男3贾婕，刘冬1艾伟平1(1张家口市第一医院神经内一科河北张家口075000;2张家口市第一医院神经外科河北张家口075000;3张家口市第一医院呼吸三科河北张家口075000)摘要目的:探究合并不同发作形式的快速眼动睡眠期行为障碍(RBD)与帕金森病的临床特点及自主神经功能障碍变化_方法：采用快速眼动期睡眠行为障碍筛查量表及帕金森综合评分量表（UnifiedParkinson’sdiseaseratingscale),对20例合并简单型(RBD)的帕金森病患者(RBD-简单组）与20例合并复杂型（RBD)的帕金森病患者（RBD-复杂组)进行研究结果：两组帕金森病患者的一般情况、左旋多巴药物日剂量、疾病病程等无统计学差异(P>0.05)。合并复杂型（RBD)的帕金森病患者运动部分评分高于合并简单型（RBD)的帕金森病患者(PC0.05)。两组患者之间在非震颤、强直、运动减少症状均存在统计学差异(P<0.05),(RBD)复杂组评分均高于（RBD)简单组，多因素丨ogistics回归显示，复杂型（RBD)的存在与UPDRS-山部分评分相关，而与年龄、病程、教育年限、左旋多巴药物日剂量等无显著相关，与运动减少症状最为相关，与震颤、非震颤、强直症状无相关性,，两组患者运动障碍类型与（RBD)发作形式无明显相关性(卢0.108)_结论：合并复杂型（RBD)的帕金森病患者运动症状更重，并且累及运动障碍的诸多方面帕金森病患者存在复杂型（RBD)症状主要与UPDRS-UJ评分相关，其中与运动减少方面显著相关..，关键词：快速眼动睡眠行为障碍；帕金森病；自主神经功能障碍中图分类号：R742.5文献标识码：A文章编号：1673-6273(2021)06-丨174-04ClinicalFeaturesofParkinson'sDiseasewithBehavioralDisorderDuringRapidEyeMovementSleep*ZHANGJing1,WUXiao-yurr,WANGJun-nan3,JIAJie'tLIUDong1,AIWei-ping1(1DepartmentofNeurology,FirstHospitalofZhangjiakou,Zhangjiakou,Hebei,075000,China;2DepartmentofNeurosurgery,FirstHospitalofZhangjiakou,Zhangjiakou,Hebei,075000,China;3No.lHospitalofZhangjiakou,No.3respiratorydepartment,Zhangjiakou,Hebei,075000,China)ABSTRACTObjective:ToexploretheclinicalfeaturesandautonomicnervedysfunctionofREMsleepbehaviordisorderandParkinson'sdiseasecombinedwithdifferentseizureforms.Methods:20patientswithParkinson'sdiseasecombinedwithsimpleRBD(RBD-simplegroup)and20patientswithcomplexRBD-complexgroup(RBD-complexgroup)werecomparedandstudiedbyusingtheRAPIDeyemovementsleepbehaviordisorderscreeningscaleandtheUnifiedParkinson'sDiseaseRatingScale.Results:Therewerenosignificantdifferencesinthegeneralcondition,dailydoseoflevodopadrug,andthecourseofdiseasebetweenthetwogroups(P>0.05).ThemotorscoresofParkinson'sdiseasepatientswithcomplexRBDwerehigherthanthoseofParkinson'sdiseasepatientswithsimpleRBD(P<0.05).Therewerestatisticaldifferencesinnon-tremor,rigidity,andreducedmotorsymptomsbetweenthetwogroups(P<0.05).ThescoresoftheRBDcomplexgroupwerehigherthanthoseoftheRBDsimplegroup.MultivariatelogisticregressionshowedthattheexistenceofcomplexRBDwasrelatedtopartialscoresofUPDRS-I1I,butnotsignificantlyrelatedtoage,courseofdisease,yearsofedu­cation,dailydoseoflevodopadrug,etc.,andwasmostrelatedtoreducedsymptomsofexercise,andwasnotrelatedtothesymptomsoftremor,nontremorandrigidity.TherewasnosignificantcorrelationbetweenthetypeofmovementdisorderandtheformofRBDinthetwogroups(P=0.108).Conclusion:PdpatientswithcomplexRBDhavemoreseveremotorsymptomsandinvolvemanyaspectsofmotordisorders,whichisassociatedwithUPDRS-HIscore,andismostrelatedtoreducedsymptomsofexercise.Keywords:RAPIDeyemovementsleepbehaviordisorder;Parkinson'sdisease;Autonomicn...