Primaryclearcellcarcinomaintheliver:CTandMRIfindingsQing-YuLiu,MingGao,Xiao-FengLin,YongLi,Jian-YuChen,DepartmentofRadiology,TheSecondAffiliatedHospitalofSunYat-senUniversity,Guangzhou510120,GuangdongProv-ince,ChinaHai-GangLi,DepartmentofPathology,TheSecondAffili-atedHospitalofSunYat-senUniversity,Guangzhou510120,GuangdongProvince,ChinaAuthorcontributions:LiuQYdesignedthestudyandwrotethemanuscript;GaoM,LiYandChenJYcontributedtotheanaly-sisandinterpretationofdata;LiHGperformedthepathologicalanalysis;LinXFcontributedtothestatisticalanalysis.Correspondenceto:Qing-YuLiu,PhD,DepartmentofRadiol-ogy,TheSecondAffiliatedHospitalofSunYat-senUniversity,107YanJiangXiRoad,Guangzhou510120,GuangdongProv-ince,China.liu.qingyu@163.comTelephone:+86-20-81332243Fax:+86-20-81332702Received:August29,2010Revised:December1,2010Accepted:December8,2010Publishedonline:February21,2011AbstractAIM:Toretrospectivelyanalyzethecomputedtomogra-phy(CT)andmagneticresonanceimaging(MRI)appear-ancesofprimaryclearcellcarcinomaoftheliver(PCCCL)andcomparetheimagingappearancesofPCCCLandcom-montypehepatocellularcarcinoma(CHCC)todeterminewhetheranydifferencesexistbetweenthetwogroups.METHODS:TwentycaseswithpathologicallyprovenPCCCLand127caseswithCHCCintheSecondAffili-atedHospitalofSunYat-senUniversitywereincludedinthisstudy.CTorMRIimagesfromthesepatientswereretrospectivelyanalyzed.Thefollowingimagingfindingswerereviewed:thepresenceoflivercirrhosis,tumorsize,theenhancementpatternondynamiccontrastscanning,thepresenceofpseudocapsules,tumorrup-ture,portalveinthrombosisandlymphnodemetastasis.RESULTS:BothPCCCLandCHCCwerepronetooccurinpatientswithlivercirrhosis,theassociationrateoflivercirrhosiswas80.0%and78.7%,respectively(P>0.05).ThemeansizesofPCCCLandCHCCtumorswere(7.28±4.25)cmand(6.96±3.98)cm,respectively.SmallHCCswerefoundin25.0%(5/20)ofPCCCLand19.7%(25/127)ofCHCCcases.Nosignificantdiffer-encesinmeansizeandratioofsmallHCCswerefoundbetweenthetwogroups(P=0.658and0.803,respec-tively).ComparedwithCHCCpatients,PCCCLpatientsweremorepronetoformpseudocapsules(49.6%vs75.0%,P=0.034).Tumorrupture,typicalHCCen-hancementpatternsandportalveintumorthrombosisweredetectedin15.0%(3/20),72.2%(13/18)and20.0%(4/20)ofpatientswithPCCCLand3.1%(4/127),83.6%(97/116)and17.3%(22/127)ofpatientswithCHCC,respectively.Therewerenosignificantdifferenc-esbetweenthetwogroups(allP>0.05).NopatientswithPCCCLand2.4%(3/127)ofpatientswithCHCCshowedsignsoflymphnodemetastasis(P>0.05).CONCLUSION:TheimagingcharacteristicsofPCCCLaresimilartothoseofCHCCandcouldbeusefulfordif-ferentiatingthesefromotherlivertumors(suchashem-angiomaandhepaticmetastases).PCCCLsaremorepronethanCHCCstoformpseudocapsules.©2011Baishideng.Allrightsreserved.Keywords:Clearcellcarcinoma;Hepatocellularcarcino-ma;Pathology;Magneticresonanceimaging;ComputedTomography;X-rayPeerreviewers:CTriantopoulou,MD,PhD,HeadofRadiologyDepartment,KonstantopouleiogeneralHospital,3-5,AgiasOlgasstreet,14233N.Ionia,Athens,Greece;HiroshiYoshida,Associ-ateProfessor,DepartmentofSurgery,NipponMedicalSchoolTamaNagayamaHospital,1-7-1Nagayama,Tama-city,Tokyo,206-8512,JapanLiuQY,LiHG,GaoM,LinXF,LiY,ChenJY.Primaryclearcellcarcinomaintheliver:CTandMRIfindings.WorldJGastroenterol2011;17(7):946-952Availablefrom:URL:http://www.wjgnet.com/1007-9327/full/v17/i7/946.htmDOI:http://dx.doi.org/10.3748/wjg.v17.i7.946Qing-YuLiu,Ha...
