多发性硬化 发病机制VIP免费

国际免疫学杂志2006年3月第29卷第2期Intematiohalo，March2006，Vol29．No．2(34)：235—244．9CortesiniR。LeMaoultJ，CiubotariuR，eta1．CD8CD28一Tsuppressorcellsandtheinductionofantigen-specific，antigen-presentingcell-mediat-edsuppressionofThreactivity．InanunolRev．2001，182：2ol-206．10ChangCC，CiubotariuR，ManavalanJS，eta1．T0lerizationofdendriticcellsbyT(S)cells：thecrucialroleofinhibitoryreceptorsILT3andILT4．NatImmunol，2002，3(3)：237．243．1lMullerAJ．Pr~ldergustGC．Marryingimmunothempywithchemotherapy：whysayIDO?CancerRes，2005，65(18)：8065-8068．12MellorAL。MunnDH．IDOexpressionbydendriticceils：toleranceandtryptophancatabolism．NatRevInmmnol，2OO4，4(10)：762-774．13MellorAL，SivakuII1arJ。ChandlerP，eta1．PreventionofTcel1．drivancomplementactivationandinflammationbytryptophancatabolismduringpregnancy．NatImmunol，2001。2(1)：64-68．14GunnerGJ，NewberryIl1)，SchloemannSR，eta1．Inhibitionofindoleam．ine2．3-dioxygenaseaugmentstrinitrobenzenesulfonicacidcolitisinmice．Gastroenterology，2003，125(6)：l762-1773．15HwangSL，ChugNP，Chan雎，eta1．Indoleamine2，3-dioxygenase(IDO)isessentialfordendriticcellactivationandchemotacticrespons．多发性硬化的发病机制董梅ivenesstochemokines，CelRes，2O05，15(3)：l67．175．16FmmentoG。RotondoR，TonettiM，eta1．Tryptophan-derivedcatabolitesresponsibleforinhibitionofTandnaturalkillercelproliferationin-ducedbyindoleamine2，3-dioxygenase．JExpMed，2002，196(4)：459-468．17SilvaNM，RedriguesCV，SantomMM，eta1．Expressionofindoleamine2。3-dioxygenase，tryptophmadegradation，andkynurenineformationdur-inginvivoinfectionwithToxoplasmagondii：inductionbyendogenousgammainterferonandrequirementofinterferonregulatoryfactor1．InfectImmun。2OO2，70(2)：859868．18BraunD，LangtrrmRS，AlbertML．Atwo-stepinductionofindoleamine2，3dioxyge,ur~(IDO)activityduringdendritic-cellmaturation．Blood，2005，l06(7)：2375．2381．19GrohmannU，舢arinoF。SilaS，eta1．CD4oligationablatesthetolero-genicpotentialoflymphoiddordriticcells．JImmunol，2Ix)l，166(1)：277．283．20GrohmannU。FallarinoF，PaceettiP．Tolerance，DCsandtryptophan：muchadoaboutIDO，TrendsImmunol，2003。24(5)：2d2．248．(收稿日期：2005—03一l1)摘要多发性硬化是中枢神经系统炎性脱髓鞘疾病，有遗传易感性，与环境因素有关，其病因和发病机制尚未阐明，近年的研究表明它具有多种发病机制，并依此提出许多新论点和观念，我们对此进行了综述。关键词多发性硬化；病理；发病机制文章编号1673—4394(2006)02—0100—03中图分类号R744．51文献标识码AThePathogenesisofMultipleSclerosisD0NGMei(TheSecondAfiliatedHospitalofttebeiMedicalUniversity，Shifiazhuang050000，China)AbstractMultiplesclerosis(MS)ischaracterizedbydemyelinationandinflammationofcentralnervoussystem(CNS)，whichgenerallyOCcursingeneticallysusceptiblepeopleenvironmentagentsmayhaveimportantroles，itsetiologicalfactorsandpathogenesyareunclear．ThecurrentresearahfindingsindicatethatMShasdiferentpathologicalpatternsanditisaheterogeneousdisease0fCNS；axonalinjuryduringtheearlycourseofMSandlossofneuroncellindicatethatotherpatho．genesisexistsinMS；frequentrelapsesandcontinuousprogressionofthediseasemaybeconcemedwithcontinuousacquisitionofnewself-recognizedantigensandmatrixmetallopmteinases(MMPs)作者单位：050000石家庄，河北医科火学第二医院(博士研究生)审校者：河北医科大学第二医院李春岩维普资讯http://www.cqvip.com垦匪鱼瘴堂盘查生3筮塑鲞箜JournalofIrrmmn010，h2006，Vol29．N...