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多发性硬化 发病机制VIP免费

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国际免疫学杂志2006年3月第29卷第2期Intematiohalo,March2006,Vol29.No.2(34):235—244.9CortesiniR。LeMaoultJ,CiubotariuR,eta1.CD8CD28一Tsuppressorcellsandtheinductionofantigen-specific,antigen-presentingcell-mediat-edsuppressionofThreactivity.InanunolRev.2001,182:2ol-206.10ChangCC,CiubotariuR,ManavalanJS,eta1.T0lerizationofdendriticcellsbyT(S)cells:thecrucialroleofinhibitoryreceptorsILT3andILT4.NatImmunol,2002,3(3):237.243.1lMullerAJ.Pr~ldergustGC.Marryingimmunothempywithchemotherapy:whysayIDO?CancerRes,2005,65(18):8065-8068.12MellorAL。MunnDH.IDOexpressionbydendriticceils:toleranceandtryptophancatabolism.NatRevInmmnol,2OO4,4(10):762-774.13MellorAL,SivakuII1arJ。ChandlerP,eta1.PreventionofTcel1.drivancomplementactivationandinflammationbytryptophancatabolismduringpregnancy.NatImmunol,2001。2(1):64-68.14GunnerGJ,NewberryIl1),SchloemannSR,eta1.Inhibitionofindoleam.ine2.3-dioxygenaseaugmentstrinitrobenzenesulfonicacidcolitisinmice.Gastroenterology,2003,125(6):l762-1773.15HwangSL,ChugNP,Chan雎,eta1.Indoleamine2,3-dioxygenase(IDO)isessentialfordendriticcellactivationandchemotacticrespons.多发性硬化的发病机制董梅ivenesstochemokines,CelRes,2O05,15(3):l67.175.16FmmentoG。RotondoR,TonettiM,eta1.Tryptophan-derivedcatabolitesresponsibleforinhibitionofTandnaturalkillercelproliferationin-ducedbyindoleamine2,3-dioxygenase.JExpMed,2002,196(4):459-468.17SilvaNM,RedriguesCV,SantomMM,eta1.Expressionofindoleamine2。3-dioxygenase,tryptophmadegradation,andkynurenineformationdur-inginvivoinfectionwithToxoplasmagondii:inductionbyendogenousgammainterferonandrequirementofinterferonregulatoryfactor1.InfectImmun。2OO2,70(2):859868.18BraunD,LangtrrmRS,AlbertML.Atwo-stepinductionofindoleamine2,3dioxyge,ur~(IDO)activityduringdendritic-cellmaturation.Blood,2005,l06(7):2375.2381.19GrohmannU,舢arinoF。SilaS,eta1.CD4oligationablatesthetolero-genicpotentialoflymphoiddordriticcells.JImmunol,2Ix)l,166(1):277.283.20GrohmannU。FallarinoF,PaceettiP.Tolerance,DCsandtryptophan:muchadoaboutIDO,TrendsImmunol,2003。24(5):2d2.248.(收稿日期:2005—03一l1)摘要多发性硬化是中枢神经系统炎性脱髓鞘疾病,有遗传易感性,与环境因素有关,其病因和发病机制尚未阐明,近年的研究表明它具有多种发病机制,并依此提出许多新论点和观念,我们对此进行了综述。关键词多发性硬化;病理;发病机制文章编号1673—4394(2006)02—0100—03中图分类号R744.51文献标识码AThePathogenesisofMultipleSclerosisD0NGMei(TheSecondAfiliatedHospitalofttebeiMedicalUniversity,Shifiazhuang050000,China)AbstractMultiplesclerosis(MS)ischaracterizedbydemyelinationandinflammationofcentralnervoussystem(CNS),whichgenerallyOCcursingeneticallysusceptiblepeopleenvironmentagentsmayhaveimportantroles,itsetiologicalfactorsandpathogenesyareunclear.ThecurrentresearahfindingsindicatethatMShasdiferentpathologicalpatternsanditisaheterogeneousdisease0fCNS;axonalinjuryduringtheearlycourseofMSandlossofneuroncellindicatethatotherpatho.genesisexistsinMS;frequentrelapsesandcontinuousprogressionofthediseasemaybeconcemedwithcontinuousacquisitionofnewself-recognizedantigensandmatrixmetallopmteinases(MMPs)作者单位:050000石家庄,河北医科火学第二医院(博士研究生)审校者:河北医科大学第二医院李春岩维普资讯http://www.cqvip.com垦匪鱼瘴堂盘查生3筮塑鲞箜JournalofIrrmmn010,h2006,Vol29.N...

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