·临床研究·倡通讯作者：王志明，Ｅｍａｉｌ：ｗｚｍ０１０９８＠１２６．ｃｏｍ骨质疏松与腰椎退行性变的相关性分析王志明倡杨雄健吴俊哲陈敢峰广东省中山市中医院骨一科，广东中山５２８４００中图分类号：Ｒ４４文献标识码：Ａ文章编号：１００６-７１０８（２０１４）０２-０１７８-０４摘要：目的探讨骨质疏松与腰椎退行性变之间的内在联系，为临床预测疾病的预后、并进而采取相应的措施阻止或延缓疾病的发展进程提供客观的临床依据。方法本研究采用随机对照研究方法，随机抽取在我院住院患者１８０例，测试骨密度，据此分为３组：骨量正常组、骨量减少组及骨质疏松组，分别拍摄腰椎正侧位Ｘ-ｒａｙ片，测量骨赘积分、椎间盘高度及椎体形变。结果Ｎａｔｈａｎ积分比较，骨质疏松组与骨量减少组及骨量正常组间有显著性差异（P＜０畅０５），骨量减少组及骨量正常组无显著性差异（P＞０畅０５）；各组之间对应节段椎间盘高度差异有显著性意义（P＜０畅０５），其中，骨质疏松组的椎间盘高度明显小于骨量减少组及骨量正常组；椎体形变在低骨量组与骨量正常组之间差异不明显（P＜０畅０５），而骨质疏松组的椎体其畸形变的程度与骨量减少组及骨量正常组差异有显著性意义（P＜０畅０５），且畸形变多发生在Ｌ１、Ｌ４、Ｌ５，以ｈａ／ｈｐ减少多见。结论骨质疏松组的腰椎退变程度最重，骨量减少组的腰椎退变程度较轻，骨量正常组的腰椎退变程度最轻，提示骨质疏松与腰椎退变呈正相关，骨质疏松可加速腰椎退变的进程。关键词：骨密度；骨质疏松；腰椎退行性变；相关性CorrelationalanalysisofosteoporosisandthelumbarvertebraldegenerationWANGZhiming，YANGXiongjian，WUJunzhe，CHENGanfengTheFirstDepartmentofOrthopedics，ZhongshanHospitalofTraditionalChineseMedicine，Zhongshan５２８４００，ChinaCorrespondingauthor：WANGZhiming，Email：wzm０１０９８＠１２６．comAbstract：ObjectiveToinvestigatetheinnerlinkbetweenosteoporosisandthelumbarvertebraldegeneration，inordertoprovideobjectiveclinicalbasisforforecastingtheclinicalprognosisofthediseases，andtotakeappropriatemeasuretopreventordelaythedevelopmentofthediseases．MethodsTherandomcontrolledmethodwasappliedinthisstudy．Onehundredandeightypatients，whowerehospitalizedinourhospital，wererandomlyselected．Allthepatientsweredividedinto３groupsaccordingtobonemineraldensity（BMD）：thecontrolgroup，theosteopeniagroup，andtheosteoporosisgroup．TheanteroposteriorandlateralX-rayofthelumbarvertebraeweretaken．Thenthescoreoftheosteophyte，thechangesofthelumbardischeight，andthedeformationofthevertebralbodyweremeasured．ResultsTheNathanscoresintheosteoporosisgroupweresignificantlydifferenttothatintheosteopeniagroupandthecontrolgroup（P＜０畅０５），whilenosignificantdifferencewasobservedbetweenosteopeniagroupandcontrolgroup（P＞０畅０５）．Thedifferenceoftheheightofthelumbardiscineverysegmentineachgroupwassignificant（P＜０畅０５）．Theheightofthelumbarvertebraediscsinosteoporosisgroupwassignificantlylowerthanthatinosteopeniagroupandcontrolgroup（P＜０畅０５）．Thoughthedeformationofthevertebralbodybetweenosteopeniagroupandcontrolgroupwasnotsignificant，thedeformationofthevertebralbodyinosteoporosisgroupwassignificantlydifferenttothatintheosteopeniagroupandthecontrolgroup（P＜０畅０５）．ThedeformationoftenoccurredatL１，L４，andL５，mostpresentingasthedecreaseofha／hp．ConclusionThedegenerationofthelumbarvertebraeinosteoporosisgroupisthemostsevere，thedegenerationinosteopeniagroupisless，andthedegenerationincontrolgroupistheleast．Theresultsindicatethatthereispositivecorrelationbetweenosteoporosisandthedegenerationofthelumbarvertebrae．Osteoporosiscanpromot...
