循证医学国内高压氧综合治疗突发性耳聋疗效的meta分析李曼陈晨陶泽肆陈始明dOIl0.3877/cma.j.issn.l674-0785.20l2.l9.038作者单位430060武汉大学人民医院耳鼻喉头颈外科通讯作者陶泽漳Emaiitaozezhang@l63.com"摘要#目的评价国内高压氧综合治疗突发性耳聋的疗效方法我们通过检索l997~20l2年近十五年PubmedCochranedatabaseofSystematicReviewsEmbase知网万方数据库中关于高压氧综合治疗突发性耳聋的随机对照研究RCTs同时筛检纳入文献的参考文献对纳入研究的方法学进行评价研究者对文献质量进行严格评价和资料提取对符合质量标准的RCTs用Reviewmanager5.0软件进行meta分析结果ll个RCTs共l362例患者l395耳纳入研究其中治疗组高压氧联合药物治疗682例702耳对照组单纯药物治疗680例693耳meta分析结果表明治疗组临床疗效即总有效率优于对照组P<0.0000l在病程早期应用高压氧联合药物治疗突发性耳聋的疗效要优于晚期应用P<0.0000l结论高压氧联合药物治疗突发性耳聋的疗效明显优于单纯药物治疗而且对于突发性耳聋患者在病程早期两周内应用高压氧综合治疗疗效更加显著"关键词#高压氧听觉丧失突发性治疗结果MetaanalysisofdomestictherapyeffectofhighpressureoxygenagainstsuddenhearinglossLImanCHENChenTAoZe-zhangCHENShi-ming.DepartmentofotolaryngologyHead&NeckSurgeryRenminHospitalofWuhanUniuersityWuhan430060ChinaCorrespondingauthorTAoZe-zhangEmailtaozezhang@163.comAbstractObjectiveToevaiuatecurrenttherapyeffectofhighpressureoxygenHPOagainstsuddenhearingiossSHL.MethodsSearchforRCTsindatabasessuchasPubmedCochranedatabaseofSystematicReviewsEmbaseHownetandWanfangdataregardingtoHPOcomprehensivetherapyagainstSHL.atthesametimethereferenceswerescreenedandthemethodswereevaiuated.Researcherswentthroughstrictevaiuationandextractionagainstreferenceguaiityandoniytheguaiifiedreferencesunderwentmeta-anaiysiswithReviewmanager5.0.Resultsatotaiofllstudieswithl362pooiedpatientsl395earswereinciudedwith682individuais702earsinexperimentgroupcomprehensivetherapyofHPOandmedicinetherapyand680individuais693earsincontroigroupreguiarmedicinaitreatment.meta-anaiysisresuitimpiiedthatthetotaitherapeuticeffecteffectiverateoftheexperimentgroupwassignificantiyhigherthanthecontroigroupP<0.0000latthesametimeeariyappiicationofcomprehensivetreatmentwasmoreeffectivethaniaterappiicationP<0.0000l.ConclusionsHPOcomprehensivetherapyagainstSHLismoreeffectivethansimpiemedicinaitreatmentmoreoverappiicationofHPOcomprehensivetherapyineariyphaseofSHLwithinthefirsttwoweeksofonsetismoreeffective.KeywordsHyperbaricoxygenationHearingiosssuddenTreatmentoutcome突发性耳聋suddendeafnessSd是指瞬间或几小时或3d内突然发生原因不明的一种感音神经性聋l是耳鼻喉科临床上常见的一类疾病由于它的病因及发生过程不明迄今国内外尚无公认的有效治疗手段过去临床上常以抗病毒药物类固醇类药物扩张血管药物及营养神经药物等药物单独或联合应用为主而随着高压氧治疗突发性聋的出现高压氧联合药物的综合疗法已经成为治疗突发性耳聋的一种重要治疗手段本文将检索相关文献比较高压氧综合疗法与以往单纯药物治疗突发性耳聋的疗效情况并且对早期高压氧治疗与晚期治疗的效果做一比较资料和方法一检索策略本文以中文关键词高压氧突发性耳聋英文关键词hyperbaricoxygenHBOsuddendeafnessSd检索l997~20l2年近十五年CochranedatabaseofSystematicReviewsEmbasePubmed知网万方数3495中华临床医师杂志电子版20l2年l0月第6卷第l9期ChinJCiiniciansEiectronicEditionOctoberl20l2Voi.6No.l9万方数据据库文献检索主要包括4个步骤l对各个数据库中相关的系统评价/Meta分析进行检索2检索各中英文数据库中相关的原始论文并对检索后所获得的文献题目摘要以及所用的主题词和关键词加以分析用来进一步确定用于相关文献检索的关键词3将所有相关的关键...
