临床药师向临床提供基于系统分析的循证药学证据一例VIP免费

临床药师向临床提供基于系统分析的循证药学证据一例—逍遥散方剂治疗脑卒中后抑郁疗效的 Meta 分析白慧东 1娄玉红 1 杨国萍 2 蒋玉凤 1（1 新疆自治区人民医院 乌鲁木齐 830001 , 2 新疆医科大学药学院 乌鲁木齐 830054 ）[摘要] 目的：利用荟萃分析方法对逍遥散方剂治疗脑卒中后抑郁的临床试验进行分析，评价其治疗效果。方法：检索并选取 1994-2010 年国内公开发表的有关逍遥散方剂治疗脑卒中后抑郁的临床随机对照试验文献，应用 Jadad 评分法进行质量评价，并用 RevMan 5.0 软件进行 Meta 分析。结果：共有 8 项研究符合纳入标准。与阳性对照组比较，逍遥散方剂治疗脑卒中后抑郁的有效率无显著性差异（P＞0.05）。逍遥散用药前后比较 PSD 患者的HAMD 评分有显著差异。与阳性对照组比较，逍遥散方剂治疗脑卒中后抑郁的 HAMD 评分无统计学差异（P＞0.05）。单用逍遥散方剂与逍遥散方剂联合氟西汀治疗 PSD 患者的 HAMD评分无显著性差异。结论：逍遥散方剂治疗 PSD 临床效果肯定，与阳性对照组无统计学差异，但逍遥散与氟西汀合用无明显的药效学协同作用。关键词 逍遥散方剂；脑卒中后抑郁；Meta 分析Meta analysis of XiaoYaoSan in the treatment of post stroke depressionBAI Hui-Dong1 LOU Yu-Hong YANG Guo-Ping2(1.People’s Hospital of Xinjiang Uygur Autonomous Region, XinJiang Urumqi 830001,China;2.XinJiang medical university , XinJiang Urumqi 830054,China ）ABSTRACT: OBJECTIVE To conduct a Meta analysis on the clinical trials of XiaoYaoSan for post stroke depression（PSD） and evaluate its therapeutic efficacy. METHODS The related reports concerning the clinical trials of XiaoYaoSan in treating post stroke depression published domestically between 1994 and 2010 was retrieved, and Meta analysis was conducted on the selected reports by means of Review Manager 5.0 . The quality of reports of randomized clinical trials were evaluated according to the method given by Jadad. RESULTS There are 8 reports matches our including standard. Comparing with positive control ,the efficiency of XiaoYaoS...