下载后可任意编辑年产 110 吨肝素酶发酵车间工艺设计12024 年 4 月 19 日下载后可任意编辑年产 110 吨肝素酶发酵车间工艺设计摘要肝素酶指一类能够特异性裂解肝素和类肝素主链糖苷键的酶,被用于清除血液中的肝素,测定肝素的结构,以及抗肿瘤等医学方面的讨论。国外对肝素酶的讨论已有 40 多年历史,涵盖菌种筛选、发酵产酶、分离纯化、克隆表示等领域。中国起步很晚,当前仅见中科院(北京)微生物讨论所和四川大学有关于肝素酶讨论的报道。当前世界上讨论最多、最深化的肝素酶依旧由肝素黄杆菌发酵生产而来。本文经过肝素酶发酵工艺的讨论,包括灭菌工艺讨论、提取工艺的讨论、浓缩和干燥工艺讨论及成型工艺讨论,将其研制成工艺切实可行、质量稳定可控的酶制剂。并对肝素酶制剂车间生产工艺进行讨论,对工艺流程、物料衡算、热量衡算、车间布置、管道布置、三废处理、设备造型等关键工艺进行设计,为肝素酶车22024 年 4 月 19 日下载后可任意编辑间工艺的设计提供依据。关键词:肝素酶;车间布置;工艺流程图32024 年 4 月 19 日下载后可任意编辑AbstractIn these pieces is in under the guidance of TCM theory, combined with clinical doctors the application and selected clinical experience for many years, has qingrejiedu, spleen and stomach, invigorate the circulation of bulge, clinically used for chronic gastritis, gastric ulcer, accompanied by intestinal metaplasia atypical symptoms.His own by these, spreading hedyotis herb, rhizoma coptidis, etc of ten herbs, of which one of these for his own gentleman medicine, therefore, in these extraction technology on the basis of the experimental research, the application form of his 42024 年 4 月 19 日下载后可任意编辑own from the traditional one, developed into taking convenient oral solid preparation, change one carry inconvenience, shortcomings and so on perishable.In this article, through these pieces of research of preparation process, including crushing and sterilization technology research, the extraction process of study, concentration and drying proc...
