精品文档---下载后可任意编辑eIF4E、VEGF--C 在食管癌中的表达以及与淋巴转移的关系的开题报告Introduction:Esophageal cancer is one of the most aggressive malignancies with high mortality rates. It is known that lymph node metastasis is the main reason for the poor prognosis of esophageal cancer. As there are still no effective biomarkers for predicting lymph node metastasis, identifying novel prognostic markers for esophageal cancer is crucial.Objectives:The aim of this study is to investigate the expression of eIF4E and VEGF-C in esophageal cancer tissues and their correlation with lymph node metastasis.Methods:A total of 80 patients with esophageal cancer who underwent surgical treatment and lymph node dissection were enrolled in this study. Immunohistochemistry (IHC) was used to determine the expression levels of eIF4E and VEGF-C in the cancer tissues. Statistical analysis was used to evaluate the correlation between eIF4E and VEGF-C expression with lymph node metastasis.Results:The expression of eIF4E and VEGF-C was significantly higher in esophageal cancer tissues compared with adjacent normal tissues. In addition, higher expression of eIF4E and VEGF-C was significantly correlated with the presence of lymph node metastasis. The positive expression rates of eIF4E and VEGF-C were 60% and 62.5%, respectively, in lymph node-positive patients, whereas in lymph node-negative patients, the rates were 25% and 30%, respectively. Furthermore, there was a significant correlation between the expression of eIF4E and VEGF-C in esophageal cancer tissues.Conclusions:This study demonstrated that eIF4E and VEGF-C are highly expressed in esophageal cancer tissues and are correlated 精品文档---下载后可任意编辑with lymph node metastasis. Therefore, eIF4E and VEGF-C may serve as potential prognostic markers for esophageal cancer.
