精品文档---下载后可任意编辑HOXA11 β-catenin 和 DKK-1 在子宫内膜癌中的表达及意义的开题报告【摘要】子宫内膜癌是女性生殖系统常见的恶性肿瘤之一，其发病率逐年上升。本讨论旨在探究 HOXA11、β-catenin 和 DKK-1 在子宫内膜癌中的表达及其意义。采纳免疫组织化学方法检测 HOXA11、β-catenin 和 DKK-1 在子宫内膜癌患者和正常人群中的表达水平，并进行统计学分析。结果显示，子宫内膜癌患者中 HOXA11 和 β-catenin 的表达水平显著高于正常人群，而 DKK-1 的表达水平则显著低于正常人群。此外，HOXA11 和 β-catenin 的表达水平与子宫内膜癌的分级、分期、浸润深度有显著相关性，而 DKK-1 的表达水平在这些指标上则没有显著相关性。综上所述，HOXA11 和 β-catenin 的高表达可能在子宫内膜癌的发生和进展中扮演重要角色，而 DKK-1 的低表达则可能与其相关。这些发现可以为子宫内膜癌的诊断、治疗和预后评估提供重要的理论基础和临床指导。【关键词】子宫内膜癌；HOXA11；β-catenin；DKK-1；免疫组织化学【Abstract】Endometrial cancer is one of the common malignant tumors in the female reproductive system, and its incidence is increasing year by year. This study aimed to explore the expression and significance of HOXA11, β-catenin and DKK-1 in endometrial cancer. The expression levels of HOXA11, β-catenin and DKK-1 in endometrial cancer patients and normal population were detected by immunohistochemistry and statistically analyzed. The results showed that the expression levels of HOXA11 and β-catenin in endometrial cancer patients were significantly higher than those in normal population, while the expression level of DKK-1 was significantly lower than that in normal population. In addition, the expression levels of HOXA11 and β-catenin were significantly correlated with the grade, stage and infiltration depth of endometrial cancer, while the expression level of DKK-1 was not significantly correlated with these indicators. In conclusion, high expression levels of HOXA11 and β-catenin may play important roles in the occurrence and development of endometrial cancer, while low expression level of DKK-1 may be related to it. These findings can provide important theoretical basis and clinical guidance for the diagnosis, treatment and prognosis evaluation of endometrial cancer.精品文档---下载后可任意编辑【Keywords】Endometrial cancer; HOXA11; β-catenin; DKK-1; Immunohistochemistry
