精品文档---下载后可任意编辑S100B 蛋白表达与早发型及晚发型子痫前期发病的关系的开题报告摘要子痫前期是妊娠期最常见的疾病之一，其发病机制尚未完全明确。讨论表明 S100B 蛋白在子痫前期的发生中起重要作用。本讨论旨在探究S100B 蛋白表达与早发型及晚发型子痫前期发病的关系。本讨论采纳回顾性病例对比讨论的方法，选取早发型子痫前期患者、晚发型子痫前期患者及正常孕妇作为对比组。采纳免疫组织化学方法检测 S100B 蛋白的表达情况，并进行统计学分析。结果显示，与对比组相比，早发型子痫前期组和晚发型子痫前期组S100B 蛋白表达显著增加（P<0.05）。此外，在早发型子痫前期组中，S100B 蛋白表达明显高于晚发型子痫前期组，差异有统计学意义（P<0.05）。综上所述，S100B 蛋白表达与早发型及晚发型子痫前期发病有关，并且在早发型子痫前期的发病中，S100B 蛋白可能发挥着更重要的作用。这一讨论结果可以为临床上子痫前期早期诊断和预防提供一定的参考价值。关键词：S100B 蛋白；子痫前期；早发型；晚发型；免疫组织化学。AbstractPreeclampsia is one of the most common diseases during pregnancy, and its pathogenesis is not yet fully understood. Studies have shown that S100B protein plays an important role in the occurrence of preeclampsia. This study aimed to explore the relationship between S100B protein expression and the occurrence of early-onset and late-onset preeclampsia.A retrospective case-control study was conducted, and early-onset preeclampsia patients, late-onset preeclampsia patients, and normal pregnant women were selected as the control group. Immunohistochemistry was used to detect S100B protein expression and statistical analysis was performed.The results showed that S100B protein expression in the early-onset and late-onset preeclampsia groups was significantly increased compared with the control group 精品文档---下载后可任意编辑(P<0.05). In addition, S100B protein expression in the early-onset preeclampsia group was significantly higher than that in the late-onset preeclampsia group, with statistical significance (P<0.05).In conclusion, S100B protein expression is related to the occurrence of early-onset and late-onset preeclampsia, and S100B protein may play a more important role in the occurrence of early-onset preeclampsia. These results can provide some reference value for the early diagnosis and prevention of preeclampsia in clinical practice.Keywords: S100B protein; preeclampsia; early-onset; late-onset; immunohistochemistry.
