精品文档---下载后可任意编辑“肝脾”为核心干预高催乳激素血症大鼠卵巢颗粒细胞凋亡机制初探的开题报告摘要：本讨论旨在探究高催乳激素血症大鼠卵巢颗粒细胞凋亡机制及肝脾作为其核心干预方式的可行性。采纳乳腺分泌物过多性大鼠模型，通过检测血清中催乳激素水平和卵巢颗粒细胞凋亡指标，发现高催乳激素血症可导致卵巢颗粒细胞凋亡的增加。同时，观察到肝脾对催乳激素水平和卵巢颗粒细胞凋亡均有调节作用，故提出肝脾作为核心干预高催乳激素血症大鼠卵巢颗粒细胞凋亡的治疗方案，进一步阐述其作用机制，并探究其在临床应用中的可行性和安全性。关键词：高催乳激素血症、卵巢颗粒细胞凋亡、肝脾、核心干预Abstract:This study aims to explore the apoptosis mechanism of ovarian granulosa cells in rats with hyperprolactinemia and the feasibility of liver and spleen as the core intervention method. A model of rat with excessive mammary secretion was used, and by detecting the level of prolactin in serum and the apoptosis index of ovarian granulosa cells, it was found that hyperprolactinemia may lead to an increase in granulosa cell apoptosis. At the same time, it was observed that liver and spleen have a regulatory effect on prolactin levels and ovarian granulosa cell apoptosis. Therefore, we propose a treatment plan for liver and spleen as the core intervention for the apoptosis of ovarian granulosa cells in rats with hyperprolactinemia, further elucidate its mechanism of action, and explore its feasibility and safety in clinical applications.Keywords: hyperprolactinemia, apoptosis of ovarian granulosa cells, liver and spleen, core intervention.
