精品文档---下载后可任意编辑间歇胰岛素泵联合瑞格列奈强化治疗儿童青少年 2 型糖尿病的开题报告摘要：本文旨在探讨间歇胰岛素泵联合瑞格列奈强化治疗儿童青少年 2 型糖尿病的可行性和效果，并对该讨论进行开题分析和设计。针对儿童青少年 2 型糖尿病对胰岛素使用的限制和对口服降糖药物不敏感的情况，本讨论采纳间歇胰岛素泵联合瑞格列奈强化治疗方案，旨在探究其治疗效果及安全性。本讨论拟采纳前瞻性、随机、双盲、平行对比的临床讨论设计，招募符合入选标准的儿童青少年 2 型糖尿病患者，随机分成两组，一组接受常规治疗，另一组接受间歇胰岛素泵联合瑞格列奈强化治疗。讨论期为 6 个月，中期和结束时对两组患者进行生化指标、胰岛素用量、血糖测定和身体质量指数等方面数据的收集与比较分析，进行结局评价。本讨论估计能探究间歇胰岛素泵联合瑞格列奈强化治疗儿童青少年2 型糖尿病的治疗效果，为临床治疗提供更有效的手段。关键词：2 型糖尿病；儿童青少年；间歇胰岛素泵；瑞格列奈；临床讨论Abstract:The purpose of this article is to explore the feasibility and effectiveness of the combination of intermittent insulin pump and rglitinide in the treatment of type 2 diabetes in children and adolescents, and to conduct an opening analysis and design of the study. In response to the limitations of insulin use for type 2 diabetes in children and adolescents and the insensitivity to oral hypoglycemic agents, this study uses an intermittent insulin pump combined with rglitinide to explore the efficacy and safety of treatment.This study plans to adopt a prospective, randomized, double-blind, parallel-controlled clinical research design, and recruit children and adolescents with type 2 diabetes who meet the selection criteria. They will be randomly divided into two groups, one group receiving conventional treatment, and the other group receiving intermittent insulin pump combined with rglitinide augmented treatment. The study period is 6 months, and mid-term and end-term data collection, including 精品文档---下载后可任意编辑biochemical indicators, insulin usage, blood glucose measurement, and body mass index, will be analyzed and compared between the two groups for outcome evaluation.This study is expected to explore the therapeutic effects of intermittent insulin pump combined with rglitinide in the treatment of type 2 diabetes in children and adolescents and provide a more effective means for clinical treatment.Keywords: Type 2 diabetes, Children and adolescents, Intermittent insulin pump, Rglitinide, Clinical research.
