The chemical tool of claim 21 wherein the restriction endonuclease for targeting DNA sequences is selected from the group consisting of:Sequence cutEnzyme Name SEQ ID NO:AAR/AATTYAcsI53R/AATTYApoI53A/AGCTTHindIII54AA/CGTTPsp140 6I55AAT/ATTSspI56ACA/CRYGTAflIII57A/CCGGTAgeI58A/CATGTBspLU11I59ACCTGC(4,8)BspMI60, 61ACTGG(1,�6�11)BsrI62, 63R/CCGGYBsrFI64R/CCGGYCfr10I64A/CGTMaeII65A/CGCGTMluI66RCATG/YNspI67A/CCGGTPinAI58A/CCWGGTSexAI68A/CTAGTSpeI69AGAGG/CCTAatI70AG/CTAluI71A/GATCTBglII72R/GATCYBstYI73RG/GNCCYDraII74AGC/GCTEco47III75RG/GNCCYEcoO109I74RGCGC/YHaeII76RG/GWCCYPpuMI77AGT/ACTScaI78AGG/CCTStuI70R/GATCYXhoII73ATAT/TAATAseI79AT/TAATAsnI79AT/CGATBspDI80AT/CGATClaI80ATGCA/TNsiI81ATTT/AAATSwaI82CACAGNNN/CTGAlwNI83CAC/GTGBbrPI84CACNNN/GTGDraIII85YAC/GTRBsaAI86C/AATTGMfeI87C/AATTGMunI87CA