丙酮酸-2-呋喃酰腙二邻氯苄基锡配合物的合成及性质 化学专业

丙酮酸-2-呋喃酰腙二邻氯苄基锡配合物的合成及性质摘 要：丙酮酸-2-呋喃酰腙和二邻氯苄基二氯化锡反应，合成了丙酮酸-2-呋喃酰腙二邻氯苄基锡配合物，通过元素分析、IR、HRMS、1H NMR、13C NMR、119Sn NMR、TGA 及 X-射线单晶衍射等方法表征了配合物 C1 的分子结构，采用 MTT 方法对配合物 C1 进行生物活性实验，结果表明：配合物分子的中心锡原子为七配位畸变五角双锥构型，该配合物 C1 对癌细胞 MCF7的抑制效果较好。关键词：二邻氯苄基锡；酰腙；合成；生物活性 Synthesis and property of pyruvate-2-furanohydrazone di-o-chlorobenzyltin complexAbstract : Pyruvate-2-furanohydrazone di-o-chlorobenzyltin was synthesized by the reaction of Pyruvate-2-furanohydrazone and di-o-chlorobenzyltin dichloride. The complex has been characterized by IR, HRMS, 1H NMR, 13C NMR, 119Sn NMR spectra, elemental analysis and the crystal structure has been determined by X-ray diffraction. The biological activity of the complex was tested by MTT. The central tin atom of the complex is a seven-coordination pentagonal pentagon configuration, and the complex C1 has a better inhibitory effect on cancer cell MCF7.Keywords : di-o-chlorobenzyltin; hydrazone; synthesis; biological activity目录1 引言................................................................................................................11.1 有机锡化合物的发展.................................................................................11.2 有机锡的用途.............................................................................................11.3 酰腙类化合物的发展.................................................................................21.4 选题目的及论文的研究内容.....................................................................22 实验部分........................................................................................................32.1 仪器和试剂..................................................................................