疾病状态下的中药药代动力学研究进展VIP专享

[摘要]近年来，越来越多的讨论表明中药的药代动力学特征能够被疾病状态所影响，生理及病理的变化在一定程度上会影响机体内的药物代谢酶、转运蛋白、细胞膜的通透性以及微生物菌群的改变，从而改变中药在机体内的吸收、分布、代谢和排泄过程，进而引起中药的药代动力学参数的改变。鉴于中药主要是用于病理状态的机体内，故讨论机体病理状态下的药动学参数较正常状态下更有意义。该文拟就中药在糖尿病、脑缺血、肝损伤、炎性疾病、神经系统疾病以及发热等疾病状态下的药代动力学的讨论作一综述，以期为临床针对不同的机体状态，设计合理安全的用药剂量提供一定的参考。[关键词]药代动力学;病理状态;药物代谢酶;转运蛋白Advances on pharmacokinetics of traditional Chinesemedicine under disease statesGONG Zi-peng ， CHEN Ying ， ZHANG Rui-jie ， YANG Qing ， ZHU Xiao-xin*（Institute of Chinese Materia Medica ， China Academy of Chinese Medical Sciences ，Beijing 100700 ， China）[Abstract]In recent years ， more and more research shows that the pharmacokinetic parameter of traditional Chinese medicine can be affected by the disease states. It′s possible that drug metabolic enzymes ， transporters ， cell membrane permeability and the change of microbes group could be interfered with physiological and pathological changes ， which enables the pharmacokinetics of traditional Chinese medicine in the body to be altered ， including the process of absorption ， distribution ， metabolism and excretion ， and then the pharmacokinetic parameters of traditional chinese medicine are altered. It′s found that investigating the pharmacokinetic of traditional chinese medicine in the pathological state is more useful than that of in normal state because the great part of traditional Chinese medicine is mainly used to treat disease. This article reflects the latest research on the pharmacokinetic of traditional Chinese medicine in the disease state such a...