文拉法辛联合利培酮治疗精神病性抑郁症对比讨论【摘要】 目的 讨论文拉法辛联合利培酮治疗精神病性抑郁症的临床疗效及安全性。 方法 将 80 例精神病性抑郁症患者随机分为两组各 40 例,两组均口服利培酮治疗,讨论组联合文拉法辛治疗,对比组联合阿米替林治疗,观察 6 w。于治疗前及治疗第 1 w、2 w、4 w、6 w 末采纳汉密顿抑郁量表、简明精神病量表、临床疗效总评量表、副反应量表评定临床疗效及不良反应。 结果 治疗 6 w 末抑郁症状讨论组显效率为 78%,对比组为 75%;精神病性症状讨论组显效率为 80%,对比组为 83%,两组总体疗效相当。汉密顿抑郁量表、简明精神病量表总分及临床疗效总评量表评分两组治疗 1 w 末起均较治疗前有显着下降;但讨论组治疗 2 w 末汉密顿抑郁量表评分及 4 w 末简明精神病量表、临床疗效总评量表评分均较对比组下降显着。副反应量表评分讨论组治疗 1 w、2 w、4 w、6 w 末均显着低于对比组,讨论组静坐不能、嗜睡、心电图改变、震颤不良反应发生率均显着低于对比组。 结论 两组总体临床疗效相当,但讨论组起效更快、安全性更高、依从性更好。【关键词】 精神病性抑郁症;文拉法辛;阿米替林;利培酮 【Abstract】 Objective To study the clinical efficacy and safety of venlafaxine combined with risperidone in the treatment of psychotic depression. Methods 80 patients with psychotic depression were randomly divided into research group taking orally risperidone combined with velafaxine and control group risperidone with amitriptyline for 6 weeks. Clinical efficacy was assessed with the Hamilton Depression Scale,the Brief Psychiatric Rating Scale and Clinical Global Impression and adverse effect with the Treatment Emergent Symptom Scale before treatment and at the end of the 1st,2nd,4th and 6th week treatment. Results At the end of the 6th week,excellence rates were respectively 78% in the research group and 75% in the control;excellence rates of psychotic symptoms were 80% in the research and 83% in the control respectively,total efficacies of the 2 gro...