·综述·分子印迹整体材料在固相萃取中的应用及展望摘要:分子印迹整体柱结合了分子印迹技术的高立体选择性和整体柱制备过程简单、易于修饰改性、重复性好以及传质速度快等优点, 是固相萃取材料的进展趋势和前沿课题。介绍了分子印迹聚合物整体材料在与高效液相色谱和毛细管液相色谱法联用技术方面的应用阐述了固相微萃取技术及其应用.并对分子印迹整体材料在固相萃取方面的进展趋势作了简要展望。关键词:分子印迹;整体柱;固相萃取;综述Applications of Molecular Imprinted Monolithic Material in Solid—Phase ExtractionAbstract : The molecular imprinted monolithic column is the trend of development and the advanced task of the solid phase extraction materials, due to it combine with high selectivity of the molecular imprinting technology (MIT) and simple preparation, easy modification , high reproducibility and rapid mass transport of the monolithic column。 In this paper, the application of molecularly imprinted polymersmonolithic materials in high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) were summarized。 We also introduce the technology and application of solid phase microextractoin (SPME)。 And then the developmental prospect of molecularly imprinted polymersmonolithic materials in solid phase extraction was expected.Keywords: molecular imprinting, monolithic column, solid—phase extraction, review1 分子印迹分子印迹,又称分子烙印(Molecular Imprinting),是源于分析科学、高分子材料、生命科学等学科的一门交叉科学。分子印迹技术(molecular imprinting technique,MIT)是指制备对某一特定目标分子(模板分子或印迹分子)具有高选择识别性能的聚合物的过程。其主要原理是在模板分子和功能单体的混合物中加入交联剂,引发聚合反应,生成分子印迹聚合物(molecularly imprinted polymers,MIP),当模板分子移去后,聚合物上留下的结合位点保证了MIP能在一系列结构类似的分子中,选择性识别模板分子。基于分子印迹技术所制备的分子印迹聚合物具有亲和性和选择性高、抗干扰性强和稳...