1原发性胆汁性肝硬化的实验研究第二军医大学长征医院实验诊断科中国人民解放军医学免疫诊断中心仲人前Email:rqzhong@yahoo.comWebsite:www.clinimmunchina.com2Hep-2细胞Anti-nucleardotsAnti-nuclearmembraneAMAAMAAnti-centromereHistology3naturalhistoryofPBCSelmiC,Lancet2011;377:1600–094ductopeniaandfibrosisinPBCPouponR.JournalofHepatology2010;52:745–7585-10%10-20%70-85%5PapersonPBC02004006008001000120014001600180020001945-19491950-19541955-19591960-19641965-19691970-19741975-19791980-19841985-19891990-19941995-19992000-20042005-2009OnMedlineInChinese01002003004005006007001945-19491950-19541955-19591960-19641965-19691970-19741975-19791980-19841985-19891990-19941995-19992000-20042005-2009678randomizedcontrolledtrial91011121314PBCrelatedfactorsCorpechotC,Demographic,lifestyle,medicalandfamilialfactorsassociatedwithprimarybiliarycirrhosis.JHepatol2010;53:162–16915Annualincidenceandprevalence/100,000ofPBCStudyYearCaseno.IncidencePrevalenceMethodsSheffield,UK1980340.585.4PS,AMAMalmo,Sweden1984331.49.2HREASL19845690.40.5–7.5PSOrebro,Sweden1985361.412.8AMANewcastle,UK19893471.1–1.915.4PS,AMA,HROntario,Canada19902060.332.2PSUmea,Sweden1990861.315.1PS,AMA,HRVictoria,Australia199384NA1.9PS,AMA,HREstonia1995690.232.7PS,HRJapan199512580.34–0.422.0HR,AMANewcastle,UK19971602.218–24PS,AMA,HROslo,Norway1998211.614.6HRNewcastle,UK19997703.125.1PS,HR,AMAOlmstead,USA2000462.740.2PS,AMA,HR16PBCinChinamainlandYearPBCcaseNoteIncidence/10000020016/200abnormalliverfunction3000200221/1412hospitalized148720043/5011annualphysicalexam6020104/8126annualphysicalexam49.2women>40Yrs155.8600000-800000PBC!!!JiangXH,WorldJGastroenterol,2003,9(6):1352-5LiuHY,BMCGastroentol2010;10:10017McNALLYRJQ,SeasonalVariationintheDiagnosisofPrimaryBiliaryCirrhosis:FurtherEvidenceforanEnvironmentalComponenttoEtiology.Hepatology2011;PBCinseasons18Factorspossiblyentailedinonsetandperpetuationofbile-ductinjuryinPBCSelmiC,Lancet2011;377:1600–0919PBCsequentialeventsPouponR.JHepatol2010;52:745–75820FamilialprevalenceofPBC21Humanleukocyteantigen(HLA)complexonhumanchromosome62223h246.24A744.63A2832.321A1929.219A114.63A1035.423A94.63A353.835A20.1801.7902.3100.5720.3197.4320.8370.04232.01381.98541.81800.9820.0005.6240.7280.12138.51660.9940.0003.7160.3970.71747.32040.1590.4610.5446.3271.52A1%n%nPχ2Controls(n=431)PBC(N=65)HLAPBC与HLA–A的相关性LiuHY,WorldJournalofGastroenterology,2005；11(26):4108-4110250.6790.17125.310927.718B700.9580.0032.3101.51B670.0703.2973.5159.26B480.4880.48013.96010.87B460.2291.4463.71600B400.7880.0722.8123.12B370.1591.98110.94716.911B350.4010.7064.4197.75B270.7780.07918.68618.512B220.1661.9149.74215.410B210.6380.2221.461.51B180.5070.43912.1529.26B170.1861.75020.99013.89B150.1252.3511.254.63B140.6520.20216.27018.512B130.8680.0284.2184.63B120.6380.2221.6700B80.2840.1503.21400B70.4170.65916.27012.38B5Pχ2Controls(n=431)n%PBC(n=65)n%HLAPBC与HLA–B的相关性26DRB1allelesPBC(n=65)Controls(n=431)PPcORn%n%*0111.5214.90.371*031218.4317.20.006NS*041523.19622.30.885*071929.26013.90.0020.0222.55*081116.96214.40.590*092436.913832.00.432*1011.5102.30.690*1146.26214.40.069*121116.912428.80.045NS*1357.76515.10.111*1434.65312.30.068*151218.56515.10.483*1657.7163.70.248PBC与HLA–DRB1的相关性DRB1*07亚型分析•DRB1*07：0701、0703～0706•19例DRB1*07阳性PBC病人均为0701,未检测到其它亚型．27PBC患者中DRB1*0701对临床特征的影响Gender（M/F...
