文献汇报文献汇报文献汇报文献汇报主要内容主要内容•引言•仿生合成•晶体生长基本原理•羟基磷灰石•羟基磷灰石研究现状引言引言仿生合成仿生合成生物矿物合成--模板合成法模板合成方法中，模板只是提供一个支架让不同材料在一定位置形成纳米材料，其结构与模板的形状互补，所以可以合成一些一般方法很难合成的纳米结构或其它复杂有序的超级结构。双亲嵌段共聚物包含一个与无机矿物质表面强烈作用的亲水段(绑缚嵌段)和另外一个作用很弱但可以提高水中溶解性的亲水段(溶剂化嵌段).晶体生长的基本原理仿生合成制备鲍鱼壳结构示意图羟基磷灰石（HAP)简介•羟基磷灰石是组成人体骨骼和牙齿的重要组成部分，HAP是一种生物活性材料，具有良好的生物相容性、生物活性和生物稳定性，广泛应用于生物医药，催化和污水处理等领域。纳米羟基磷灰石在其功能上有一定的特性，如可以对一些肿瘤具有抑制作用,可以作为药物缓释材料抗生素、抗炎类等药物缓释载体，并且还可以作为某些化学反应的催化剂。纳米羟基磷灰石文献综述•纳米HAP的制备方法主要有共沉淀法、水热法、溶胶-凝胶法、仿生合成和溶剂热法等。SupportedSilver-Nanoparticle-CatalyzedHighlyEfficientAqueousOxidationofPhenylsilanestoSilanolsTakatoMitsudome,ShusukeArita,HaruhikoMori,TomooMizugaki,KoichiroJitsukawa,andKiyotomiKaneda*Angew.Chem.Int.Ed.2008,47,7938–7940GoldSupportedonHydroxyapatiteasaVersatileMultifunctionalCatalystfortheDirectTandemSynthesisofIminesandOximesHaoSun,Fang-ZhengSu,JiNi,YongCao,*He-YongHe,andKang-NianFanAngew.Chem.Int.Ed.2009,48,4390–4393主要内容Silanolsbuildingblocksforsilicon-basedpolymericmaterialsnucleophiliccouplingpartnersinorganicsynthesistoxicreagentsandvastwastesynthesizedNewideaAg-HAPhighcataliticactivitieswaterasanoxidantwithoutorganicsolventsAg-HAP合成Ca5(PO4)3(OH)Ca/P=1.682.0gAgNO36.7×10-3M150ml加入室温下搅拌6小时solid硼氢化钠还原Ag-HAPBioactive,luminescentandmesoporouseuropium-dopedhydroxyapatiteasadrugcarrierPiaopingYanga,b,ZeweiQuanb,ChunxiaLib,XiaojiaoKangb,HongzhouLianb,JunLinb,*aCollegeofMaterialScienceandChemicalEngineering,HarbinEngineeringUniversity,Harbin150001,PRChinabStateKeylaboratoryofRareEarthResourceUtilization,ChangchunInstituteofAppliedChemistry,ChineseAcademyofSciences,Changchun130022,PRChinaBiomaterials29(2008)4341–4347MultifunctionalHydroxyapatiteNanofibersandMicrobeltsasDrugCarriersZhiyaoHou,PiaopingYang,HongzhouLian,LiliWang,CuimiaoZhang,ChunxiaLi,RuitaoChai,ZiyongCheng,andJunLin*[a]Chem.Eur.J.2009,15,6973–6982主要内容主要内容noveldrugstorage/releasesystemsconventionalformsofdosage相比优点1.加强生物药效2.高功效3.安全性4.可控性5.延长释药时间HAPbiocompatibleosteoconductivenontoxicnoninflammatorygoodpropertiesdrugcarriers•Therefore,thedesignanddevelopmentofluminescencefunctionalizedHAPwithnano-sizedandmesoporouscharacteristicsshouldbeabletoreachthisgoal.•Herein,theyproposetheone-stepsynthesisofnovelluminescencefunctionalizedmesoporousHAPmaterialsbydropingEu3+duringthesynthesisofmesoporousHAP,resultingintheformatingofmultifunctionalmaterimal.•合成发光功能的中孔羟基磷灰石3.168g(NH4）2HPO48.740gCTAB100ml去离子水PH=12+4.218gCaCl20.676gEu(NO3)260ml去离子水中孔羟基磷灰石•ItisfoundthatbothpureHAPandEu:HAPconsistofrelativelyuniformrod-likeparticleswiththewidthof20-40nmandthelengthof100-200nm.TheresultssuggestthatthedropingofEu3+haslittleinfluenceonthemorphologyofpureHAP.•Thismaterialishierarchicallystructuredandexhibitsananoscalerod-like,mesoporous,crystallinestructure,whichissuitablefordrug(IBU)releaseasadrugcarrier.Especially,itexhibitsstrongredlu...
