肝脏滤泡树突状细胞肉瘤临床病理特征VIP免费

1I|导拳^i鬟牝奈塞'@wqd@wjgnet．com百世量西；·IIideng~世界华人消化杂志2O10年11月28日；18(33)：3520—3526ISSN1009—3079(print)ISSN2219-2859(online)肝脏滤泡树突状细胞肉瘤临床病理特征黄海建，余英豪，郑智勇一背景资料肝脏滤泡树突状细胞肉瘤(FDCS)系由肝组织内滤泡树突状细胞发生的一类恶性肿瘤．与肝细胞癌或其他的肝脏恶性肿瘤相比。FDCS的临床表现、形态学特征及预后等均有显著差异，因此肝脏FDCS的准确诊断对于提高该类肿瘤的认识显得尤为重要．黄海建．福建医科大学福州总医院临床学院中国解放军南京军区福州总医院病理科福建省福州市350025余英豪，郑智勇，中国解放军南京军区福州总医院病理科福建省福州市350025黄海建，2008级福建医科大学硕士，主要从事肝脏病理学研究．作者贡献分布：本研究由黄海建设计：研究过程由黄海建、余英豪及郑智勇完成：本论文写作由黄海建完成．通讯作者：郑智勇，教授，主任医lJ币，350025，福建省福州市西二环北路156号，中国解放军南京军区福州总医院病理科．768203566@qqcom电话：0591—24937095传真：0591—83717703收稿日期：2010—08—31修回日期：2010—10—20接受日期：2010—10—26在线出版日期：2010—11—28CIinicopathologiCfeaturesofhepaticfolliculardendriticcellSarcomaHai-3ianHuang，Ying-HaoYu，Zhi-YongZhengHal-3ianHuang，FuzhouGeneralCliIlicalSchool，FujianMedicalUniversity；DepartmentofPathology，FuzhouGeneralHospitalofNaniingMilitaryCornmandofChinesePLA．Fuzhou350025．FuiianProvince，ChinaYing-HaoYu，Zhi-~ongZheng，DepartmentofPathology,FuzhouGeneralHospitalofNanjingMilitaryCommandofChinesePLA，Fuzhou350025，FujianProvince，ChinaCorrespondenceto：ProfessorZhi-YongZheng．Depart—mentofPathology．FuzhouGeneralHospita1ofNanjingMilitaryCommandofChinesePLA．156NorthXierhuanRoad，Fuzhou350025，FuiianProvince，China．768203566@qq．comReceived：201O—O8．31Revised：2010—1O一2OAccepted：2010—10．26Publishedonline：2010．1l一28AbstractAIM：Toinvestigatetheclinicopathologicfea—turesdiagnosistreatmentandprognosisofhe—paticfolliculardendriticcellsarcoma．METHODS：Theclinical，pathologicalandim—munohistochemicaldataforthreepatientswithhepaticfolliculardendriticcellsarcomawhoweretreatedatourhospita1werecollectedtoanalyzetheclinicopathologicfeatures，diagno。sis，treatmentandprognosisofthedisease．Aliteraturereviewwasalsoperformedtorevealthecharacteristicsofthedisease．●同行评议者垂篓主RES⋯ULTS：Alal⋯thetumo。rs⋯show⋯edaninfiltread-军北京军区总医nVegrowtnpattem·1wotumOrswerelocated院病理科intheleftlobeoftheliver,andoneintherightlobe．Histopatholog3,revealedco-existenceofthecomponentsofspindlecellsarcomaandinflam-matorycells．Coagulationnecrosiswasnotedinsomeareas．Immunohistochemicallv,tumorceUswerestronglypositiveforCD21，CD23,CD35,vi-mentin,weaklypositiveforCD45andEMA,butnegativeforcK(Pan)，CD34,CD117,Dog-1，actin,SMA，caldesmon,desmin,CD10，CD15，CD30，CD1a，ALK，CD68，CD163，HMB45andS-100．In-flammatoryceHswerepositiveforCD20，CD79a，CD2，CD3，CD45R0andCD38．Inallthreecases,tumorcellswerepositiveforEBERandEBV．Adiagnosisofhepaticfolliculardendriticcellsar—comawasmade．CONCLUSlON：Hepaticfolliculardendriticcellsarcomaisararetumorwithahighdegreeofmalignancyandshouldbedifferentiatedfrominterdigitatin~dendriticcellsarcoma，sarcoma．toidhepatocellu1arcarcinoma，inflammatorymyofibroblastoma,extra—gastrointestinalstromaltumor,andhistiocytosarcoma。KeyWords：Liverneoplasm；Hepaticfollicularden-driticcellsarcoma；ClInicOpath0IOgy；DiferentialdiagnosisHuangHJ，YuYH，ZhengZY．Clinicopathologicfeaturesof...