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儿童血栓性血小板减少性紫癜VIP免费

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书第14卷第11期2012年11月中国当代儿科杂志ChinJContempPediatrVol.14No.11Nov.2012[Received]June15,2012;[Revised]August9,2012[Biographyofthefirstauthor]MelanieSTEELE,female,amedicalstudentofMichaelG.DeGrooteSchoolofMedicine,McMasterUniversity.[Correspondenceauthor]Dr.KeithK.LAU,MBBS,FRCPC,FAAP,FRCPCH,FRCP(Glasgow),AssociateProfessor,DepartmentofPediatrics,McMasterUniversity,Hamilton,Ontario,Canada.Email:kelau@mcmaster.ca.·国外研究动向·ThromboticthrombocytopenicpurpurainpediatricpatientsMelanieSTEELE1,HowardH.W.CHEN(陈浩伟)2,JeremySTEELE3,AnthonyK.C.CHAN(陈锦泉)4,KeithK.LAU(刘广洪)5(1.MichaelG.DeGrooteSchoolofMedicine,McMasterUniversity,Hamilton,Ontario,Canada;2.ThrombosisandAtherosclerosisResearchInstitute,Hamilton,Ontario,Canada;3.SUNYUpstateUniversityMedicalCenter,GolisanoChildren′sHospital,Syracuse,NewYork,USA;4.DepartmentofPediatrics,McMasterUniversity,Hamilton,Ontario,Canada;5.DepartmentofPediatrics,McMasterUniversity,Hamilton,Ontario,Canada)Abstract:Althoughthromboticthrombocytopenicpurpura(TTP)israrelyseeninpediatricpatients,failuretorecognizethisconditionoftenleadstosevereconsequencesandpooroutcomes.ClassicfeaturesofTTPincludethrombocytopenia,microangiopathichemolyticanemia,acutekidneyinjury,fever,andcentralnervoussysteminvolvement.However,patientssufferingfromthisconditionmaynotpresentwithallofthesymptomssimultaneously.Therefore,itisofutmostimportanceforhealthcareproviderstohaveahighindexofsuspicion.Laboratoryinvestigationsmayrevealthepresenceofschistocytesonperipheralbloodsmear,negativeCoombstest,highlactatedehydrogenaselevelsandseverelylowplateletcounts.TheetiologyofTTPismainlyduetoinsufficientcleavageofthelargemultimersofvonWillebrandfactor(vWF)secondarytode...

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儿童血栓性血小板减少性紫癜

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