1)硝酸盐或亚硝酸盐导致头痛(热狗头痛);2)谷氨酸单钠导致头痛(中国餐馆综合征);3)一氧化碳导致头痛;4)酒精导致头痛;5)其他物质。51212某些物质慢性应用或接触所致的头痛①每天应用或接触。②必有引致头痛的最小剂量。③头痛为慢性(≥15日或1个月)。④停用后1个月内头痛消失。1)麦角胺导致头痛;2)镇痛药导致头痛;3)其他物质。51213某些物质戒断引起的头痛如麦角胺、咖啡因的戒断。6治疗611急性药源性头痛61111停止用导致DIH的药物61112控制其他不良反应如颅高压、无菌性脑膜炎的脱水降颅压等处理;急性脑病的抗脑水肿、减轻免疫性损伤、改善脑营养代谢等的治疗。61113对症治疗如镇静、抗惊厥等。612慢性药源性头痛61211逐渐减量至停用。61212对症治疗如镇静、改善睡眠等。7预防711宣传教育712合理用药小剂量、单药或联用、短疗程等。713制定社区或家庭用药计划。参考文献1TothC.MedicationsandSubstancesasaCauseofHeadache:Asystem2aticreviewoftheliterature.ClinicalNeuropharmacology.2003,26(3):122-136.2LimmrothV,KatsaravaZ,FritscheG,etal.Featuresofmedicationoveruseheadachefollowingoveruseofdifferentacuteheadachedrugs.Neurology.2002,59:(7)1011-1014.3HeadacheClassificationCommitteeoftheInternationalHeadacheSociety.Classificationanddiagnosticcriteriaforheadachedisorders,cranialneu2ralgia,andfacialpain.Cephalalgia.1988,8(suppl.7):1-96.泰勒宁胶囊用于中晚期癌痛镇痛疗效的临床评价陈金生广州医学院第二附属医院广东广州510260EVALUATIONTHEANALGESICEFFECTSOFCOMPOUNDCAPSULEOFOXYCODONEANDACETAMINOPHENONMODERATEANDADVANCEDCANCERPAINChenJinsheng【摘要】目的评价泰勒宁胶囊用于中晚期癌痛的镇痛效果并与曲马多胶囊比较。方法58例中晚期癌痛患者随机分为泰勒宁组(T组n=30)和曲马多组(Q组n=28);用双盲法观察两组病人的镇痛效果、不良反应。结果两组病人均取得良好的镇痛疗效,用药7d后中度以上疼痛缓解率和完全缓解率,T组分别为100%和83,3%;Q组分别为9614%和7114%,两组相比较差异无显著性(P>0105);用药期间有部分患者出现头晕、嗜睡和恶心、呕吐,皮肤瘙痒,皮疹,未见明显的呼吸抑制及精神依赖性。结论泰勒宁胶囊为临床药物治疗癌痛提供了一个新的选择。【关键词】癌痛药物泰勒宁曲马多药物疗效Evaluationtheanalgesiceffectsofcompoundcapsuleofoxycodoneandacetaminophenonmoderateandadvancedcancerpain/ChenJinsheng【Abstract】Objective:Tocomparetheanalgesiceffectsofcompoundcapsuleofoxycodoneandacetaminophen(Ty2lox)onadvancedcancerpainwithTramadol.Methods:Patientswererandomlydividedintotwogroups:Tyloxgroup(groupT,n=30)andTramadolgroup(groupQ,n=28).Theanalgesiceffectsandsideeffectswereobservedandrecord2edwithdoubledlindmethod.Results:Therapeuticeffectsweregoodinpatientsofbothgroups.Painreliefandcompletereliefrateformoderatepainafter7dayswere100%and8313%respectivelyingroupTand9614%and7114%respec221现代医院2004年2月第4卷第2期ModernHospitalFeb2004Vol4No2©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.tivelyingroupQ.Therewerenosignificantdifferencesbetweentwogroups.Sideeffectssuchasdizziness,lethargy,nau2sea,vomiting,pruritus,andskineruptionwerepresentinsomepatients.Therewerenoobviousrespiratorydepressionandpsychologicaldependence.Conclusions:Tyloxsuppliesanewchoiceforcanerpaintreatment.【KeyWords】CancerPain,Drug,Tylox,Tramadol,Efficacy【Author’saddress】Departmentofanesthesiology,secondaffiliatedhospitalofGuangzhoumedicalcollege,clinicalpaincenter510260口服镇痛药物仍是目前处理中晚期癌痛的主要方法和有效手段之一[1]。泰勒宁胶囊(compoundcap2suleofoxycodoneandacetaminophen商品名Tylox)为盐酸羟考酮与对乙酰氨基酚的复方麻醉性镇痛新药。我们对其在临床应用于中晚期癌痛患者的镇痛疗效和不良反应进行了观察并与曲马多胶囊...
