织病理学资料。观察结果:结肠镜检查发现7例(女性6例)阑尾黏液囊肿患者,其中3例主诉右下腹痛。所有7例患者均接受手术切除,组织病理学显示均为黏液囊腺瘤,无1例恶性肿瘤,亦未发现与该病相关的死亡病例。结论:阑尾黏液囊肿在结肠镜下表现为盲肠阑尾开口处光滑的球茎状黏膜下病灶。由于结肠镜能够准确诊断并可直接处理,因而结肠镜的识别作用非常重要。阑尾黏液囊肿有由于可能恶变或因穿孔导致腹膜假性黏液瘤形成的风险,因此推荐手术切除。(0053—0056尹勇译)GT200554/9消化道0057.Incompletescreeningflexiblesigmoidoscopyassociatedwithfemalesex,age,andin-creasedriskofcolorectalcancerDoria.Rose尸./NewcombPA./Levin兄【Dr.V.P.Doria,Rose.FredHutchinsonCancerResearchCenter.1100FairviewAveNorth,Seattle,WA98109—1024.UnitedStates]一GUT2005,54/9(1273—1278)Background:Severalpreviousstudieshavefoundthatfe-malesandolderindividualsareatgreaterriskofhavingincompleteflexiblesigmoidoscopy.However,nopriorstudyhasreportedthesubsequentriskofcolorectalcancer(CRC)followingincompletesigmoidoscopy.Methods:Usingdatafrom55791individualsscreenedaspartoftheColonCancerPrevention(CoCaP)programmeofKaiserPermanenteofNorthernCalifornia.weevaluatedthelike-lihoodofhavinganinadequate(<40cm)examinationbyageandsex,andestimatedtheriskofdistalCRCaccordingtodepthofsigmoidoscopeinsertionatthebaselinescreen-ingexamination.Multivariateestimationofriskswasper-formedusingPoissonregression.Results:Olderindividu-alswereatamuchgreaterriskofhavinganinadequateexamination(relativerisk(RR)forage80+yearscom—paredwith50—59years2.6(95%confidenceinterval(CI)2.3—3.0)),aswerefemales(RR2.3(95%CI2.2~2.5));theseassociationswereattenuatedbutre-mainedstrongifPoissonmodelswerefurtheradjustedforexaminationlimitations(pain,stool,andangulation).TherewasanapproximatethreefoldincreaseintheriskofdistalCRCifthebaselinesigmoidoscopydidnotreachadepthofatleast40cm;asmallerincreaseinriskwasobservedforexaminationsthatreached40—59cm.Con-clusions:Olderindividualsandwomenareatanincreasedriskofhavinginadequatesigmoidoscopy.Becauseinade-quatesigmoidoscopyresultsinanincreasedriskofsubsequentCRC,physiciansshouldconsiderstepstomaximisethedepthofinsertionofthesigmoidoscopeor,failingthis,shouldconsideranalternativescreeningtest.因女性、年龄及结肠直肠癌患病风险增加所引起的可屈性乙状结肠镜筛查结果不完全背景:许多既往研究发现对女性或年老个体进行可屈性乙状结肠镜检查,筛查结果不完全的情况常有发牛。但是,有关乙状结肠镜不完全筛查后发生结肠直肠癌(CRC)的实际风险却鲜有报道。方法:通过分析来自北加利福尼亚KaiserPermanente结肠癌预防计划(CoCaP)的55791例筛查者,对不同年龄、性别的不完全(<40cm)检查结果。及按在基线筛查基础上乙状结肠镜送入不同深度的近端CRC发生风险进行了评价。采用Poisson回归法进行多变嚣风险评估。结果:年长个体发生筛查不完全的风险更大(>80岁50~59岁;RR2.6,95%CI2.3~3.0),女性个体(RR2.3,95%CI2.2~2.5),虽然相关性不显著,但以检查限制因素(疼痛、血便、消瘦)对Poisson模型进行校正后,则呈显著相关性。如果乙状结肠镜送入深度未达40cm,那么近端发生CRC的风险增加3倍;深度达40—59cm者,风险轻微增加。结论:老年及女性患者发生乙状结肠镜检查结果不完全的风险增加。鉴于检查结果不完全会带来实际发生CRC的风险增高,医师应当考虑尽可能地将乙状结肠镜送入深处,否则就应寻求其他筛查方法。0058.Fordycegranulesandhereditarynon-polyp-osiscolorectalcancersyndromeDeleeliceC./ParrinfS./Chitano£et以『Dr.C.DeFelice.NeonatalIntensiveCareUnit,AziendaOs—pedalie...