3结语支架内再狭窄是血管研究热点,同时也是困扰血管介入治疗进展的难题。支架内再狭窄的发生机制主要有血管弹性回缩、血栓形成、平滑肌过度增生和炎性反应等。目前针对防治支架内再狭窄的方法主要有抗血小板药物的使用、药物涂层支架的使用和新型材料支架等方面。相信随着医学和材料学研究的进展,支架内再狭窄问题终将会得到解决,从而造福于人类。参考文献[1]贾志豪,马依彤,艾尔肯阿吉.冠脉支架内再狭窄发生机制及防治研究进展[J].现代生物医学进展,2008,8(7):1346-1349.[2]FernsGA,AvadesTY.Themechanismsofcoronaryrestenosis:in-sightfromexperimentsmodels[J].IntJExpPathol,2000,81(2):63-88.[3]BaruesMJ.Collagensinatherosclerosis[J].CollRelatRes,1985,5(1):65-97.[4]KumarA,KarS,FayWP.Thrombosis,physicalactivity,andacutecoronarysyndromes[J].JApplPhysiol,2011,111(2):599-605.[5]王一平,谭华炳,贺琴.冠状动脉支架内再狭窄机制及防治研究进展[J].中西医结合心脑血管病杂志,2009,7(9):1078-1079.[6]DrachmanDE,SimonDI.Inflammationasamechanismandthera-peutictargetforin-stentrestenosis[J].CurrAtherosclerRep,2005,7(1):44-49.[7]DangasGD,CaixetaA,MehranR,etal.Frequencyandpredictorsofstentthrombosisafterpercutaneouscoronaryinterventionina-cutemyocardialinfarction[J].Circulation,2011,123(16):1745-1756.[8]SikkaP,BindraVK.Newerantithrombicdrug[J].IndianJCritCareMed,2010,14(4):188-195.[9]张庆辉,周典贵,白秀梅.冠状动脉支架再狭窄防治办法[J].中华现代内科学杂志,2006,3(11):1270-1271.[10]LeeKH,AhnY,YoonNS,etal.Aredrug-elutingstentssaferandmoreeffectivethanbare-metalstentsinpatientswithacutemyocar-dialinfarction?[J].IntHeartJ,2011,52(2):78-83.[11]PiccoloR,CassesesS,GalassoG,etal.Long-termsafetyandeffi-cacyofdrug-elutingstentsinpatientswithacutemyocardialinfarc-tion:ameta-analysisofrandomizedtrials[J].Arthrosclerosis,2011,217(1):149-157.[12]NewG,MosesJW,RoubinGS,etal.Estrogen-eluting,phosphoryl-choline-coatedstentimplantionisassociatedwithreducedneointi-malformationbutnodelayinvascularrepairinaporcinecoronarymodel[J].CatheterCardiovascInterv,2002,57(2):266-271.[13]MeqhriNW,DoniusAE,RiblettBW,etal.Directionallysolidifiedbiopolymerscaffolds:mechanicalpropertiesandendothelialcellre-sponse[J].JOM(1989),2010,62(7):71-75.[14]JeonTI,HwangSG,ParkNG,etal.Antioxidativeeffectofchitosanonchroniccarbontetrachlorideinducedhepaticinjuryinrats[J].Toxicology,2003,187(1):67-73.[15]SinhaVR,SinglaAK,WadhawanS,etal.Chitosanmicrospheresasapotentialcarrierfordrugs[J].IntJPharm,2004,274(1/2):1-33.[16]LiC,YangK,ZhangY,etal.Highlybiocompatiblemulti-walledcarbonnanotube-chitosannanoparticlehybridsasproteincarriers[J].ActaBiomater,2011,7(8):3070-3077.[17]TakeuchiH,YamamotoH,KawashimaY.Mucoadhesivenanopar-ticulatesystemsforpeptidedrugdelivery[J].AdvDrugDelivRev,2001,47(1):39-54.[18]刘宗军,孟晟,秦永文,等.壳聚糖和磷脂化壳聚糖涂层膜对血管内皮细胞生长和血液相容性的影响[J].第二军医大学学报,2007,28(1):19-22.[19]StackRS,CaliffRM,PhillipsHR,etal.InterventionalcardiaccatheterizationatDukeMedicalCenter[J].AmJCardiol,1988,62(10Pt2):3F-24F.[20]李可,卢才义.生物可降解血管内支架:希望和挑战[J].国际心血管病杂志,2009,36(4):193-195.[21]WaksmanR,PakalaR.Biodegradableandbioabsorbablestents[J].CurrPharmDes,2010,16(36):4041-4051.收稿日期:2011-07-28修回日期:2011-09-23支气管哮喘与糖皮质激素受体基因多态性的关系云哲琳△(综述),王冬梅※(审校)(内蒙古包头医学院,内蒙古包头014040)中图分类号:R562.25文献标识码:A文章编号:1006-2084(2012)01-0021-04摘要:支气管哮喘是由多种细胞及细胞组分参与的呼吸道慢性非特异性炎症,肾上...
