I330吨/年红霉素生产工厂的初步设计摘要本设计是为330吨/年红霉素生产工厂而进行的初步工艺设计。根据毕业设计大纲和设计任务要求该设计分别对各工艺作了详细阐述，以理论计算为依据，以实际工厂设计为参考，力求接近并切合实际。其主要包括生产工艺的各种指标、设备选形设计计算、物料衡算、水、电、汽的估算以及工艺流程图的设计。整个设计过程在保证达到设计要求和实际需要的前提下力求环保节能，从而能够获得更好的收益，降低对环境的影响，减少对环境的压力。最终理论计算结果在总收率65%的前提下，在发酵工段检测红霉素含量14000U/mL，成品单位为720U/mg，最终确定选用发酵罐体积为100m3（8个），一级种子发酵罐0.5m3（4个），二级种子发酵罐4m3（4个），三级种子罐32m3（4个）。提取工段总收率为70%，选取板框压滤机6个，溶媒萃取池3个，三足式离心机6个。符合设计的基本要求，同时满足国家标准。该设计成果主要采用形式为发酵车间平面布置图（1张），发酵工艺流程图（1张），发酵车间设备布置立面图（1张），提取车间设备布置图（1张）和发酵罐的三视图（1张）并编写详细数据说明书。关键词：红霉素；工艺流程；设计IIAnInitialTechnologicalDesignfor330t/aErythromycinFactoryMaoHailongBiologyEngineering0801,SchoolofEnvironmentalandBiologicalEngineering,LiaoNingShihuaUniversity,113001,FushunAbstractThissubjectisaninitialtechnologicaldesignforErythromycinwithyearoutputof330ton.Accordingtotherequirement,theprocessoferythromycinproductionandthecalculationofthemassbalanceandheatquantitybalancearecompleted.Inthissubject,allofthemprocessesareexpoundedindetail.Allthecontentsarebasedontheacademiccalculations.Werefertothepracticaldesignsincompaniesandmakeourbesttoapproachtothepractice.itmainlyincludestheproductioncrafteachkindoftarget,theequipmentchoosestheshapedesigncalculation,materialofthegraduatedarmofasteelyardcalculation,thewater,theelectricity,thesteamestimateaswellastheflowchartdesign.Theentiredesignprocessstrivestoguaranteetheachievementofthedesignrequirementsandtheactualneeds.Wealsonoticetheenvironmentalprotectionandenergyconservation,whichcanbringabetterincome,reducethediverseimpactontheenvironment,andreducethepressureontheenvironment.Undertheconditionofthefinalerythromycin'scalculation65%,thecontentoferythromycinfermentationbrothis14000U/mL.Thecontentoftheenderythromycinproductis720μ/mg.Thefinalselectionoffermenter'svolumeis100m3.Weneedeightfermenters,four0.5m3Firstseedfermenters,four4m3Secondseedfermenters,four32m3Thirdseedfermenters.TheyieldcoefficientofExtractionprocessis70%.Finally,wechose6Plateandframefilterpresses,3Solventextractionpoolsand6Centrifuge.Allinall,thedesignationmeetstheIIInormalrequirementsandmeetthenationalstandards.Intheend,thereisaFermentationfloor-plan(1),Flowchat(1),Fermentationprocessequipmentgeneralarrangement(1),Extractionprocessequipmentgeneralarrangement(1),Fermenterorthographicviews(1)andcompilationparticulardatainstructionbooklet.Keyword:Erythromycin;Process;Design1目录1.绪论..................................................................................................................................21.1红霉素的理化性质...............................................................................................21.2国内生产现状.......................................................................................................21.3红霉素销售状况...................................................................................................21.4红霉素生产的改善......................................................
