题名页葡萄球菌耐药机制的研究进展叶建国，张三微生物与感染编辑部，上海 200032基金项目：第一作者：详细联系方式（电话、E-mail）通信作者：详细联系方式（电话、E-mail）葡萄球菌耐药机制的研究进展叶建国，张三微生物与感染编辑部，上海 200032摘要：支原体目前对大环内酯类抗生素耐药形势严峻。综述肺炎支原体、人型支原体、解脲脲原体三种支原体对大环内酯类抗生素耐药机制，发现肺炎支原体耐药机制主要是药物作用靶位的异常，包括 23sRNA 和核糖体蛋白的改变；人型支原体除上述机制外，还可能存在着药物主动外排系统的作用；对解脲脲原体主要集中在药物主动外排机制的研究，尚未见其它耐药机制报道。支原体对大环内酯类抗生素耐药机制还需要更广泛、更深入的研究。关键词：肺炎支原体；人型支原体；解脲脲原体；大环内酯类；耐药机制 Reseach advances in the drug resistance mechanism of StaphylococcusYE Jian-Guo, ZHANG SanJournal of Microbes and Infection, Shanghai 200032, ChinaAbstract ： The drug resistance of mycoplasma to macrolide antibiotics is very serious at present. We review the drug resistance mechanism of three mycoplasmas including Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum to macrolide antibiotics, and find that the changes of drug binding sites including 23sRNA and ribosomal protein is the main mechanism of Mycoplasma pneumoniae to macrolide antibiotics; To Mycoplasma hominis, besides the changes of drug binding ──────────基金项目：……通信作者：张三Corresponding author. ZHANG Shan, E-mail: jmi@fudan.edu.cnsites, drug active efflux system may play an inportant role in this drug resistance. A few researches focus on the drug resistance of Ureaplasma urealyticum to macrolide antibiotics, mainly on the drug active efflux system. Other mechanism is not reported yet. Researches should go deeper to know more about the mechanism of the drug resistance of mycoplasma to macrolide antibiotics. Key words ： Mycoplasma pne...
