NEXT口腔粘膜溃疡类疾病OralUlcerativediseasesIntroductionBehÇet’sdiseaseTraumaticUlcer&TraumaticBullaRecurrentAphthousUlcerSummaryBACKReiter’sSyndromeI.Introduction1.Ulcersareoneofthemostcommontypesoflesionsseeninoralmucosa.2.Thedifferencebetweenulceranderosion.NEXTulcererosionNEXTulcererosioncontinuityofepitheliumbrokenseveresuperficialbasalcellsinvolvedfreeborderclearuncleardiseasesRAUBehcet’sdiseaseSyphilisPemphigusHerpessimplexBACKComparisonII.RecurrentAphthousUlcer1.Preface•NamerecurrentaphthousulcerRAUrecurrentaphthousstomatitisRASrecurrentoralulcerROUNEXT•TypingLehner’sclassificationminoraphthousulcer（MiAU）majoraphthousulcer（MjAU）herpetiformulcer（HU）•Characteristicrecidivityself-healingperiodicityNEXT2.Etiologyunknown•immunity:cellularimmunity,humoralimmunity,complement,autoantibody•heritage•infection：HSV•environment:psychologyNEXT•denutrition：iron,copper,zinc,folicacid,VitB12•hyperoxidedismutase•microcirculationdisturbance：lip,nail,apexlinguae•systemicfactor：ulcerationofstomach、hepatitis、colonitis、diarrhoeaNEXT3.ClinicalfeaturesminoraphthousulcermajoraphthousulcerherpetiformulcerNEXTNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10positionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymphnodesswellingfeverheadachelymphnodesswellingNEXTMinoraphthousulcersNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10positionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymphnodesswellingfeverheadachelymphnodesswellingMajoraphthousulcersNEXTPeriadenitisMucosaNecroticaRecurrensNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10positionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymphnodesswellingfeverheadachelymphnodesswellingHerpetiformulcersNEXT•disease-process24h10d-14doutbreakNEXTintermissionhealingprodromalstageulcerativestage5.Diagnosis•history•clinicalfeatureNEXT4.Pathology：nonspecificinflammation6.Differentialdiagnosis•benignulcer&malignantulcer•Necrotizingsialadenometaplasia,Behçet’sdisease,herpessimplex,hand-foot-and-mouthdiseaseNEXTbenignulcermalignantulcerageyouththeageddepthdeepDeeporshallowself-healingyesnosystemicconditiongoodcachexypathologychronicinflammationcancerrecurrenceyesnoComparisonNEXT7.Treatment•principle：symptomatictreatment•EvaluationofcurativeeffectNEXT•Topicalapplicationofasteroidointmentreducesdiscomfortanddecreasesthedurationofthelesions.Topicalanesthetics,antibiotics,mouthwashes,etc.,havebeenused.•Inseverecases,intralesionalsteroidinjectionorsystemicsteroidsinalowdose(10-20mgprednisone)for5-10daysreducethepaindramatically.BACKIII.BehÇet’sdisease1.PrefaceHulusiBehçet(1937)Behçet’sdiseaseisachronicmultisystemicinflammatorydisorderofuncertaincauseandprognosis.2.EtiologyUnknownNEXT3.Clinicalfeatures1)oralmucosa:minoraphthousulcer2)genitallesion:ulcer3)skinlesions:erythemanodosum,epifolliculitis,pustuleafterneedling4)ocularlesions:conjunctivitis,recurrentiritis5)otherssystems:joint,digestive,cardiovascular,nervous,respiratory,urinaryNEXT4.Pathology：Histopathologicchangesconsistofaperivascularmon...
