·2026·[2][3][4][5]burden：Globocan2000[J]．IntJCancer，2001，94(2)：153—156．KlugSJ，WilmotteR，SantosC，eta1．TP53polymorphism，HPVinfectionandriskofcervicalcancer[J]．CancerEpdemiolBiomar-kersPrey，2001，10(9)：1009—1011．CastleP，WacholderS，ShermanM，eta1．Absoluteriskofasub—sequentabnormalpapsmearamongoncogenichumanpapillomavir—usDNA—positive，cytologicalnegativewoman[J]．Cancer，2002，95(10)：2145—2151．HildesheimA，WangSS．Hostandviralgeneticsandriskofcervi—calcancer：areview[J]．ViresRes，2002，89(2)：229—240．BoschFX．ManosMM，MunozN，eta1．Prevalenceofhuman[6][7]MODERNONCOLOGY．Oct．2010，VOI．18，NO．10papillomavimsincervicalcancer：aworldperspective[J]．JNatCancerInst，1995，87：796—802．WellsSI，AronowBJ，WiseTM，eta1．Transcriptomesignatureofirreversiblesenescenceinhumanpapillomavims—positivecervicalcancercells[J]．ProcNatAcadSciUSA，2003，100：7093—7098．AdeJong，JMvallderHulst，GGKenter，eta1．Rapidenrich—mentofhumanpapillomavirus(HPV)一specificpolyclonalTcellpopulationsforadoptiveimmunotherapyofcervicalcancer[J]．IntJCancer，2005，114(2)：274—282．(编校：何姝)核转录因子E2F2在卵巢浆液性肿瘤组织中的表达及其临床意义伊喜苓一，林蓓，朱连成，王欢，从建萍，郝莹莹，梁秀云，张淑兰ExpressionofnucleartranscriptionfactorE2F2proteininovarianseroustumortissueanditsclinicalsignificanceYIxi—ling一，LINBei，ZHULian—cheng，WANGHuan，CONGJian—ping，HAOYing—ying，LIANGXiu—yun．ZHANGShu一1anDepartmentofObstetricsandGynecology，ShengfiagHospitalAfiliatedtoChinaMedicalUniversity，Shenyang110004，Chi·na；DepartmentofObstericsandGynecology，ShenyangWomenandInfantHospital，Shenyang110004，China；DepartmentofGynecol—ogy，DrumTowerHospitalAfiliatedtoNanjingUniversityMedicalSchool，Nang210008，China．【Abstract】0bjective：ToinvestigatetheexpressionofnucleartranscriptionfactorE2F2proteininovarianseroustumorsanditsclinicalsignificance．Methods：ImmunohistochemicalstainingwasusedtodeterminetheexpressionofE2F2proteinin33casesofovarianserouscystadenocarcinama，11casesofborderlineserouscystadenoma，13casesofserousadenomasand12casesofnormalovariantissues．Results：ThepositiveratesofE2F2proteininserouscystade—nocarcinama，borderlineserouscystadenoma，serousadenomasandnormalovariantissueswere72．73％，54．55％，15．38％，8．3％，respectively．Thepositiverateswerecomparedamongthefourgroups，anditpresentasignificantdifferences(P<0．05)betweenserouscystadenocarcinama，borderlineserouscystadenomaandserousadenomas，nor-malovariantissuesrespectivly，butnosignificantdifferenceswereobservedbetweenserouscystadenocarcinamaandborderlineserouscystadenoma，serousadenomasandnormaltissues(P>0．05)．Inserouscystadenocarcinama，thepositiveratesofE2F'2proteinwereincreasingwithrisingofpathologicstaging(P<0．05)，butnorelationshipwithpathologicgrade，lymphonodes(P>0．05)．Inserouscystadenocarcinama，thepositivelevelofE2F2proteinwasin—creasingwiththerisingofpathologicstagingandthedepressingofpathologicgrade(P<0．05)，butnosignificantdifferencesbetweenitandlymphonodes(P>0．05)．Conclusion：TheexpressionsofE2F2proteinweresignificantly【收稿13期】【修回13期】【基金项目】【作者单位】【作者简介】【通讯作者】2009一l2—302Ol0—03—09国家自然科学基金资助项目(编号：30170980，30571958，30872757)；辽宁省教育厅攻关项目(编号：20121268)；辽宁省自然基金资助项目(编号：20052107)；教育部博士点基金资助项...
