第31卷第5期2013年5月中华中医药学刊CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEVol.31No.5May2013中华中医药1156学刊黄芪注射液治疗变异型心绞痛及对内皮功能的影响巫莹钢1,俞进2(1.衢州市衢江区人民医院心血管内科,浙江衢州324000;2.平湖市第一人民医院消化内科,浙江嘉兴314200)摘要:目的:评价黄芪注射液治疗变异型心绞痛的疗效及对患者内皮素-1(Endothelin-1,ET-1)及一氧化氮(Nitricoxide,NO)水平的影响。方法:60例变异型心绞痛患者,按随机数字表法分为观察组和对照组。对照组:采用硝苯地平片、阿司匹林肠溶片及阿托伐他汀钙片治疗。观察组:在对照组方法的基础上,加用黄芪注射液治疗变异型心绞痛。结果:观察组总有效率86.67%高于对照组总有效率63.33%,差异有统计学意义(P<0.05)。与对照组相比,观察组能明显改善ET-1及NO水平,统计学处理,差异有显著性(P<0.01)。与对照组相比,观察组能明显降低心脏事件的发生率,统计学处理,差异有显著性(P<0.05)。结论:黄芪注射液用于治疗变异型心绞痛疗效可靠,并能明显改善变异型心绞痛患者的ET-1及NO水平。关键词:变异型心绞痛;心痛;黄芪注射液;内皮素;一氧化氮中图分类号:R259.414文献标志码:B文章编号:1673-7717(2013)05-1156-03EffectofAstragalusInjectioninTreatmentofVariantAnginaPectorisandItsInfluenceonEndothelialFunctionWUYinggang1,YUJin2(1.TheCardiovascularDepartmentofInternalMedicine,People'sHospitalofQujiangDistrict,Quzhou324000,Zhejiang,China;2.TheFirstPeople'sHospitalofPinghu,Jiaxing314200,Zhejiang,China)Abstract:Objective:TomadetherapeuticevaluationofAstragalusInjectioninthetreatmentofvariantanginapectorisanditsinfluenceonEndothelin-1(ET-1)andnitricoxide(NO).Methods:60casesofpatientswithvariantanginapecto-risweredividedintotheobservationgroupandthecontrolgroup.Thecontrolgroup:nifedipinetablets,enteric-coatedtabletsofaspirinandatorvastatincalciumtabletstreatmentofvariantanginapectoris.Theobservationgroup:onthebasisofthecontrolgroupmethod,addedAstragalusInjectioninthetreatmentofvariantanginapectoris.Results:Thetotaleffi-ciencyoftheobservationgroupwas86.67%whichwashigherthan63.33%ofthecontrolgroup,withsignificantdiffer-ence(P<0.05).Comparedwiththecontrolgroup,theobservationgroupcanimprovethelevelsofET-1andNO,withstatisticallysignificantdifference(P<0.01).Comparedwiththecontrolgroup,theobservationgroupcouldreducethein-cidenceofcardiacevents,withstatisticallysignificantdifference(P<0.05).Conclusion:AstragalusInjectionhasreliablecurativeeffectforthetreatmentofvariantanginapectoris,andcanobviouslyimprovetheET-1andNOofpatientswithvariantangina.Keywords:variantanginapectorispain;cardiacpain;AstragalusInjection;endothelin;nitricoxide收稿日期:2012-12-12基金项目:平湖市金桥工程资助项目(201225)作者简介:巫莹钢(1975-),男,浙江衢州人,主治医师,研究方向:心血管内科。变异型心绞痛属于祖国医学“心痛”范畴,是自发性心绞痛的一种特殊类型[1],也是心内科的常见多发病,预后较差,极易发生急性心肌梗死,甚至猝死,严重威胁患者的生命[2]。本研究中,笔者评价了黄芪注射液治疗变异型心绞痛的疗效,并观察了其对患者内皮素-1(Endothelin-1,ET-1)及一氧化氮(Nitricoxide,NO)水平的影响。现报道如下。1资料与方法1.1病例选择变异型心绞痛诊断标准依据《临床心脏病学》拟定,诊断要点[3]:(1)发作与活动无关,多发生于休息,尤以后半夜、清晨多见,含化硝苯地平片可迅速缓解。(2)发作时心电图显示ST段暂时性抬高,并涉及临近两个以上的导联,T波常增高,缓解后ST-T迅速恢复正常。(3)心肌酶学无特征性变化。纳入标准:经临床检查确诊,符合变异型心绞痛诊断标准的患者,男女不限。排除标准:近期内伴有急性心肌...