2013年6月第20卷第6期中国中医药信息杂志·5··临床论著·风咳方治疗咳嗽变异性哮喘疗效及其对血嗜酸性粒细胞和免疫球蛋白E的影响李颖,王雪京中日友好医院中医肺病科,北京100029摘要：目的观察风咳方对咳嗽变异性哮喘(CVA)的疗效及对嗜酸性粒细胞、免疫球蛋白E(Ig)的影响。方法将CVA患者89例随机分为治疗组59例和对照组30例,分别予风咳方和常规西药治疗,疗程4周。观察治疗前后症状积分、血中嗜酸性细胞计数、IgE计数、肺功能及支气管激发试验。结果治疗组愈显率、总有效率分别为49.2%(29/59)和91.5%(54/59),对照组愈显率、总有效率分别为40.0%(12/30)和70.7%(23/30),2组比较差异无统计学意义(P＞0.05)；治疗后2组中医证候总积分均较治疗前明显下降(P＜0.05),组间比较差异无统计学意义(P＞0.05)；治疗后治疗组血清IgE计数、嗜酸性粒细胞计数降低,与治疗前及对照组比较差异有统计学意义(P＜0.05,P＜0.01)；治疗后治疗组支气管激发试验转阴率为31.60%(18/41),对照组转阴率为25.0%(7/23),组间比较差异无统计学意义(P＞0.05)。结论风咳方对CVA患者疗效肯定,同时能明显降低血嗜酸性粒细胞和IgE计数,其治疗机理与减轻患者高敏状态有一定关系。关键词：咳嗽变异性哮喘；嗜酸性粒细胞；免疫球蛋白E；风咳方DOI：10.3969/j.issn.1005-5304.2013.06.003中图分类号：R256.11文献标识码：A文章编号：1005-5304(2013)06-0005-03TherapeuticEffectofWindCoughPrescriptiononCoughVariantAsthmaandItsInfluenceonEosnophilsandImmunoglobulinELIYing,WANGXue-jing(TCMDepartmentofPulmonaryDisease,China-JapanFriendshipHospital,Beijing100029,China)Abstract：ObjectiveToobservethetherapeuticeffectofWindCoughPrescriptiononcoughvariantasthma(CVA)anditsinfluenceoneosnophilsandimmunoglobulinE(IgE).MethodsAtotalof89casesofCVAwasrandomlydividedintotreatmentgroup(59cases)andcontrolgroup(30cases),andtreatedwithWindCoughPrescriptionandwesternmedicinerespectivelyfor4weeks.Symptomsscore,thenumberofeosnophilsandIgEintheblood,lungfunctionandbronchialprovocationtestofthetwogroupsbeforeandafterthetreatmentweredetected.ResultsThecure-remarkable-effectivenessrateandtotaleffectiveratewere49.2%(29/59)and91.5%(54/59)intreatmentgroup,and40.0%(12/30)and70.7%(23/30)incontrolgroup,showingnosignificantdifferencebetweenthetwogroups(P＞0.05).Aftertreatment,thesymptomsscoreofthetwogroupsbothdecreasedobviously,withnostatisticalsignificancebetweenthetwogroups(P＞0.05).SerumIgEandeosnophilsweredecreasedinthetreatmentgroupandcontrolgroupaftertreatmentwithstatisticalsignificance(P＜0.05,P＜0.01),andthetreatmentgroupwassuperiortothecontrolgroup.Aftertreatment,negativeconversionrateofbronchialprovocationtestinthetreatmentgroupandthecontrolgroupwas31.6%(18/41)and25.0%(7/23)respectively,withnosignificantdifferencebetweenthem(P＞0.05).ConclusionWindCoughPrescriptionhadcurativeeffectonCVA,aswellaslesseningthenumberofeosnophilsandIgEinblood.Themechanismisrelatedtorelievingthehighlysensitivestateofpatients.Keywords：coughvariantasthma；eosnophils；IgE；WindCoughPrescription咳嗽变异性哮喘(coughvariantasthma,CVA)又称隐匿型哮喘,是指以慢性咳嗽为主要或唯一临床表现的一种特殊类型哮喘,无明显喘息、气促等症状或体征,但有与哮喘发病机理相基金项目：首都医学科技发展基金(SF-2009-I-07)通讯作者：王雪京,E-mail：xuejing_wang123@sina.com同的气道高反应(bronchialhyperresponsiveness,BHR)。CVA是成人慢性咳嗽最为常见的病因之一,临床表现为刺激性干咳,症状持续时间长,达8周以上,且咳嗽比较剧烈,夜间咳嗽为其重要特征。感冒、冷空气、灰尘、油烟等容易诱发或加重咳嗽[1]。笔者以疏风解痉的风咳方治疗风邪犯肺型CVA89例,观察其对患者血嗜酸性粒细胞、免疫球蛋白E(IgE)的影响。现报道如下。·6·Chine...
