营养不良风险的慢性乙型肝炎患者甲胎蛋白_高尔基体糖蛋白73表达分析VIP免费

2011年4月第8卷第11期·论著·CHINAMEDICALHERALD中国医药导报theendotheliallymphaticmarkerD2-40isassociatedwithotherindica-torsofPoorprognosis[J].BMCCancer,2008,8:64-87.[5]KimberlyLDumoff,ChristinaChu,XiaoweiXu,etal.LowD2-40im-munoreactivitycorrelateswithLymphaticinvasionandnodalmetastasisinearly-stagesquamouscellcarcinomaoftheuterineCervix[J].Mod-ernPathology,2005,18(1):97-104.[6]Jian-guoSun,YanWang,Zheng-tangChen,etal.Detectionoflym-phangiogenesisinnon-smallcelllungcanceranditsprognosticvalue[J].JExpClinCancerRes,2009,28(1):21-45.[7]ZoltanGombos,XiaoWeiXu,ChristinaS.Chu,etal.Peritumorallym-phaticvesseldensityandvascularendothelialgrowthfactorcexpressioninearly-stagesquamouscellcarcinomaoftheuterinecervix[J].Clini-calCancerResearch,2005,11(23):8364-8371.[8]Shi-qianZhang,HaoYu,Lin-linZhang.Clinicalimplicationsofincreasedlymphvesseldensityinthelymphaticmetastasisofearly-stageinvasivecervicalcarcinoma:aclinicalimmuneohistochemicalmethodstudy[J].BMCCancer,2009,9:64-79.[9]HoshidaT,IHosakaN,HagendoornJ,etal.Imagingstepsoflymphaticmetastasisrevealsthatvascularendothelialgrowthfactor-Cincreasesmetastasisbyincreasingdeliveryofcancercellstolymphnodes:therapeuticimplications[J].CancerRes,2006,66:8065-8075.（收稿日期：2011-01-29）我国是肝炎大国，为肝癌的发生提供了庞大的基数人群。据新近统计，世界上每新增2例肝癌就有1例发生在中国，严重威胁着我国公众的生命健康，并给国家医疗资源带来了巨营养不良风险的慢性乙型肝炎患者甲胎蛋白、高尔基体糖蛋白73表达分析翁田波1，谭奕洲2，周桂华3，胡凤玉2，陈秋香4，陈星2，陈冉21.广州市第八人民医院营养科，广东广州510060；2.广州市第八人民医院检验科，广东广州510060；3.广州花都区雅瑶医院外科，广东广州510080；4.广州市第八人民医院肝病科，广东广州510060[摘要]目的：研究应用营养筛查评分简表（NRS2002）评分在甲胎蛋白（AFP）、高尔基体糖蛋白73（GP73）高表达的患者中的应用价值。方法：对206例肝炎患者体重指数（BMI）、白蛋白、AFP、GP73的测定，利用NRS2002评分简表对患者进行评分，将患者分成营养风险组（A组）和非营养风险组（B组），采用统计学方法对A、B组两组患者的AFP、GP73表达进行分析。结果：营养风险组所检测的AFP、GP73高表达率显著高于非营养风险组（P<0.05）；营养风险组的CHB、肝硬化、原发性肝癌（PHC）患者AFP、GP73的表达逐渐增加；NRS2002分值越高，AFP、GP73表达亦增高。结论：结合NRS2002评分能更多地将无AFP、GP73高表达的患者被正确区分，从而提高AFP、GP73高表达的检出率。[关键词]慢性活动性肝炎；营养风险筛查（2002）；甲胎蛋白；高尔基体糖蛋白73[中图分类号]R512.6[文献标识码]A[文章编号]1673-7210（2011）04（b）-023-03AnalysisoftheExpressionofGP73andAFPinChronicHepatitisBPatientswithMalnutritionRisksWENGTianbo1,TANYizhou2,ZHOUGuihua3,HUFengyu2,CHENQiuxiang4,CHENXing2,CHENRan21.NutritionalDepartment,theEighthPeople′sHospitalofGuangzhouCity,Guangzhou510060,China;2.DepartmentofClinicalLaboratory,theEighthPeople′sHospitalofGuangzhouCity,Guangzhou510060,China;3.SurgercalDepartment,YayaoHospitalofHuaduDistrictinGuangzhouCity,Guangzhou510080,China;4.DepartmentofHepatopathy,theEighthPeople'sHospitalofGuangzhouCity,Guangzhou510060,China[Abstract]Objective:ToinvestigatethevalueofusingNRS2002togradepatientswithhighexpressionofAFPandGP73.Methods:WiththehelpofNRS2002,thepatientswereclassifiedintonutritionriskgroup(A)andnon-nutritiongroup(B)aftertestingtheBMI,albumin,AFP,andGP73of206hepatitispatients.Bymeansofstatisticalmethods,theexpressionofAFPandGP73ofthesetwogroupswillbeanalyzed.Results:TheexpressionrateofAF...